Pikhovych, Anton, Walter, Helene L., Mahabir, Esther, Fink, Gereon Rudolf, Graf, Rudolf, Schroeter, Michael and Rueger, Maria Adele (2016). Transcranial direct current stimulation in the male mouse to promote recovery after stroke. Lab. Anim., 50 (3). S. 212 - 217. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1758-1117
Full text not available from this repository.Abstract
Transcranial direct current stimulation (tDCS) constitutes a promising approach for promoting recovery of function after stroke, although the underlying neurobiological mechanisms are unclear. To conduct translational research in animal models, stimulation parameters should not lead to neuronal lesions. Liebetanz etal. recommend charge densities for cathodal stimulation in rats, but parameters for mice are not established. We established tDCS in the wild-type mouse, enabling studies with genetically-engineered mice (GEM). tDCS equipment was adapted to fit the mouse skull. Using different polarities and charge densities, tDCS was safe to apply in the mouse where the charge density was below 198kC/m(2) for single or repeated stimulations. These findings are crucial for future investigations of the neurobiological mechanisms underlying tDCS using GEM.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-274651 | ||||||||||||||||||||||||||||||||
| DOI: | 10.1177/0023677215610708 | ||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Lab. Anim. | ||||||||||||||||||||||||||||||||
| Volume: | 50 | ||||||||||||||||||||||||||||||||
| Number: | 3 | ||||||||||||||||||||||||||||||||
| Page Range: | S. 212 - 217 | ||||||||||||||||||||||||||||||||
| Date: | 2016 | ||||||||||||||||||||||||||||||||
| Publisher: | SAGE PUBLICATIONS INC | ||||||||||||||||||||||||||||||||
| Place of Publication: | THOUSAND OAKS | ||||||||||||||||||||||||||||||||
| ISSN: | 1758-1117 | ||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/27465 |
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