Universität zu Köln

Grau, Veronika, Zeuschner, Philip ORCID: 0000-0001-8898-6588, Immenschuh, Stephan ORCID: 0000-0003-3722-5791, Bockmeyer, Clemens Luitpold, Zell, Stefanie, Wittig, Juliane, Saeuberlich, Karen, Abbas, Mahmoud, Padberg, Winfried, Meyer-Schwesinger, Catherine, von Brandenstein, Melanie, Schlosser, Monika, Dieplinger, Georg, Galliford, Jack, Clarke, Candice ORCID: 0000-0001-8576-1017, Roufosse, Candice ORCID: 0000-0002-6490-4290 and Becker, Jan Ulrich ORCID: 0000-0003-2929-8085 (2016). Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy. Transplantation, 100 (5). S. 1004 - 1015. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1534-6080

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Abstract

Background. Antibody-mediated rejection is a leading cause for renal transplant loss. Rodent models are useful to dissect pathomechanisms and to develop treatment strategies. Although used for decades as amodel, glomerular histopathological findings of Fischer-344 kidneys transplanted into Lewis rats have never been comprehensively described. Methods. Kidneys from Fischer-344 rats were transplanted into Lewis rats as life-sustaining allografts without immunosuppression. Lewis isografts and normal Fischer-344 kidneys served as controls. Grafts were harvested at 9 days, 6 and 26 weeks. Histopathological examination included lightmicroscopy, immunohistochemistry, and morphometry. Findings were compared with 51 human biopsies with transplant glomerulopathy. Results. Most glomerular findings in rat allografts resembled human acute and chronic antibody-mediated rejection with glomerulitis, microthrombosis, microaneurysms, glomerular hypertrophy, podocyte loss, glomerular basement membrane splitting, and secondary focal and segmental glomerulosclerosis. In line with previous reports on nonendothelial antigens, glomerular immunoglobulin and C4d deposition wasmostly nonendothelial. Only in 26-week allografts, we found mesangial and subendothelial immune complex-type electron-dense deposits. Similar deposits were found in 8 of 51 human biopsies with transplant glomerulopathy after rigorous exclusion of immune complexes of other cause, particularly recurrent glomerulonephritis and hepatitis C. Conclusions. Thus, our model closely reflects the glomerular changes of acute antibody-mediated rejection in humans and of a special subset of human transplant glomerulopathy. The significance of alloimmune immune complex-type deposits in human transplants deserves further investigation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grau, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeuschner, Philip UNSPECIFIED orcid.org/0000-0001-8898-6588 UNSPECIFIED Immenschuh, Stephan UNSPECIFIED orcid.org/0000-0003-3722-5791 UNSPECIFIED Bockmeyer, Clemens Luitpold UNSPECIFIED UNSPECIFIED UNSPECIFIED Zell, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittig, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Saeuberlich, Karen UNSPECIFIED UNSPECIFIED UNSPECIFIED Abbas, Mahmoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Padberg, Winfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer-Schwesinger, Catherine UNSPECIFIED UNSPECIFIED UNSPECIFIED von Brandenstein, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlosser, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Dieplinger, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Galliford, Jack UNSPECIFIED UNSPECIFIED UNSPECIFIED Clarke, Candice UNSPECIFIED orcid.org/0000-0001-8576-1017 UNSPECIFIED Roufosse, Candice UNSPECIFIED orcid.org/0000-0002-6490-4290 UNSPECIFIED Becker, Jan Ulrich UNSPECIFIED orcid.org/0000-0003-2929-8085 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276525
DOI:	10.1097/TP.0000000000001068
Journal or Publication Title:	Transplantation
Volume:	100
Number:	5
Page Range:	S. 1004 - 1015
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1534-6080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC ALLOGRAFT NEPHROPATHY; ANTIBODY-MEDIATED REJECTION; IDIOPATHIC MEMBRANOUS NEPHROPATHY; C4D DEPOSITION; PODOCYTE DEPLETION; HEYMANN NEPHRITIS; HLA ANTIBODIES; KIDNEY; GLOMERULOSCLEROSIS; RECEPTOR Multiple languages Immunology; Surgery; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27652