Warnecke-Eberz, Ute, Metzger, Ralf, Hoelscher, Arnulf H., Drebber, Uta and Bollschweiler, Elfriede (2016). Diagnostic marker signature for esophageal cancer from transcriptome analysis. Tumor Biol., 37 (5). S. 6349 - 6359. LONDON: SAGE PUBLICATIONS LTD. ISSN 1423-0380

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Abstract

Esophageal cancer is often diagnosed at an advanced stage. Diagnostic markers are needed for achieving a cure in esophageal cancer detecting and treating tumor cells earlier. In patients with locally advanced squamous cell carcinoma of the esophagus (ESCC), we profiled the gene expression of ESCC compared to corresponding normal biopsies for diagnostic markers by genome microarrays. Profiling of gene expression identified 4844 genes differentially expressed, 2122 upregulated and 2722 downregulated in ESCC. Twenty-three overexpressed candidates with best scores from significance analysis have been selected for further analysis by TaqMan low-density array-technique using a validation cohort of 40 patients. The verification rate was 100% for ESCC. Twenty-two markers were additionally overexpressed in adenocarcinoma of the esophagus (EAC). The markers significantly overexpressed already in earlier tumor stages (pT1-2) of both histological subtypes (n=19) have been clustered in a diagnostic signature: PLA2G7, PRAME, MMP1, MMP3, MMP12, LIlRB2, TREM2, CHST2, IGFBP2, IGFBP7, KCNJ8, EMILIN2, CTHRC1, EMR2, WDR72, LPCAT1, COL4A2, CCL4, and SNX10. The marker signature will be translated to clinical practice to prove its diagnostic impact. This diagnostic signature may contribute to the earlier detection of tumor cells, with the aim to complement clinical techniques resulting in the development of better detection of concepts of esophageal cancer for earlier therapy and more favorite prognosis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Warnecke-Eberz, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, Arnulf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drebber, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bollschweiler, ElfriedeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-276711
DOI: 10.1007/s13277-015-4400-4
Journal or Publication Title: Tumor Biol.
Volume: 37
Number: 5
Page Range: S. 6349 - 6359
Date: 2016
Publisher: SAGE PUBLICATIONS LTD
Place of Publication: LONDON
ISSN: 1423-0380
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BLADDER-CANCER; ADENOCARCINOMA; GENES; PROTEIN; RISK; METALLOPROTEINASES; IDENTIFICATION; EXPRESSION; INVASION; GROWTHMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27671

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