Martin, Bryn A. ORCID: 0000-0003-1234-7880, Yiallourou, Theresia I., Pahlavian, Soroush Heidari, Thyagaraj, Suraj, Bunck, Alexander C., Loth, Francis, Sheffer, Daniel B., Kroeger, Jan Robert and Stergiopulos, Nikolaos ORCID: 0000-0002-0519-0160 (2016). Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine. Ann. Biomed. Eng., 44 (5). S. 1524 - 1538. NEW YORK: SPRINGER. ISSN 1573-9686

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Abstract

For the first time, inter-operator dependence of MRI based computational fluid dynamics (CFD) modeling of cerebrospinal fluid (CSF) in the cervical spinal subarachnoid space (SSS) is evaluated. In vivo MRI flow measurements and anatomy MRI images were obtained at the cervico-medullary junction of a healthy subject and a Chiari I malformation patient. 3D anatomies of the SSS were reconstructed by manual segmentation by four independent operators for both cases. CFD results were compared at nine axial locations along the SSS in terms of hydrodynamic and geometric parameters. Intraclass correlation (ICC) assessed the inter-operator agreement for each parameter over the axial locations and coefficient of variance (CV) compared the percentage of variance for each parameter between the operators. Greater operator dependence was found for the patient (0.19 < ICC < 0.99) near the craniovertebral junction compared to the healthy subject (ICC > 0.78). For the healthy subject, hydraulic diameter and Womersley number had the least variance (CV = similar to 2%). For the patient, peak diastolic velocity and Reynolds number had the smallest variance (CV = similar to 3%). These results show a high degree of inter-operator reliability for MRI-based CFD simulations of CSF flow in the cervical spine for healthy subjects and a lower degree of reliability for patients with Type I Chiari malformation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Martin, Bryn A.UNSPECIFIEDorcid.org/0000-0003-1234-7880UNSPECIFIED
Yiallourou, Theresia I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pahlavian, Soroush HeidariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thyagaraj, SurajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bunck, Alexander C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loth, FrancisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheffer, Daniel B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroeger, Jan RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stergiopulos, NikolaosUNSPECIFIEDorcid.org/0000-0002-0519-0160UNSPECIFIED
URN: urn:nbn:de:hbz:38-277331
DOI: 10.1007/s10439-015-1449-6
Journal or Publication Title: Ann. Biomed. Eng.
Volume: 44
Number: 5
Page Range: S. 1524 - 1538
Date: 2016
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1573-9686
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHIARI-I MALFORMATION; CYCLIC CSF FLOW; FORAMEN MAGNUM; CAROTID BIFURCATION; CRANIOCERVICAL DECOMPRESSION; SUBARACHNOID SPACE; HUMAN BRAIN; SYRINGOMYELIA; REPRODUCIBILITY; HYDRODYNAMICSMultiple languages
Engineering, BiomedicalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27733

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