Universität zu Köln

Pierot, Laurent, Costalat, Vincent, Moret, Jacques, Szikora, Istvan, Klisch, Joachim, Herbreteau, Denis, Holtmannspotter, Markus, Weber, Werner, Januel, Anne-Christine, Liebig, Thomas, Sychra, Vojtech, Strasilla, Christoph, Cognard, Christophe, Bonafe, Alain, Molyneux, Andrew, Byrne, James V. and Spelle, Laurent (2016). Safety and efficacy of aneurysm treatment with WEB: results of the WEBCAST study. J. Neurosurg., 124 (5). S. 1250 - 1257. ROLLING MEADOWS: AMER ASSOC NEUROLOGICAL SURGEONS. ISSN 1933-0693

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Abstract

OBJECTIVE WEB is an innovative intrasaccular treatment for intracranial aneurysms. Preliminary series have shown good safety and efficacy. The WEB Clinical Assessment of Intrasaccular Aneurysm Therapy (WEBCAST) trial is a prospective European trial evaluating the safety and efficacy of WEB in wide-neck bifurcation aneurysms. METHODS Patients with wide-neck bifurcation aneurysms for which WEB treatment was indicated were included in this multicenter good clinical practices study. Clinical data including adverse events and clinical status at 1 and 6 months were collected and independently analyzed by a medical monitor. Six-month follow-up digital subtraction angiography was also performed and independently analyzed by a core laboratory. Success was defined at 6 months as complete occlusion or stable neck remnant, no worsening in angiographic appearance from postprocedure, and no retreatment performed or planned. RESULTS Ten European neurointerventional centers enrolled 51 patients with 51 aneurysms. Treatment with WEB was achieved in 48 of 51 aneurysms (94.1%). Adjunctive implants (coils/stents) were used in 4 of 48 aneurysms (8.3%). Thromboembolic events were observed in 9 of 51 patients (17.6%), resulting in a permanent deficit (modified Rankin Scale [mRS] Score 1) in 1 patient (2.0%). Intraoperative rupture was not observed. Morbidity (mRS score > 2) and mortality were 2.0% (1 of 51 patients, related to rupture status on entry to study) and 0.0% at 1 month, respectively. Success was achieved at 6 months in 85.4% of patients treated with WEB: 23 of 41 patients (56.1%) had complete occlusion, 12 of 41 (29.3%) had a neck remnant, and 6 of 41 (14.6%) had an aneurysm remnant. CONCLUSIONS The WEBCAST study showed good procedural and short-term safety of aneurysm treatment with WEB and good 6-month anatomical results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pierot, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED Costalat, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Moret, Jacques UNSPECIFIED UNSPECIFIED UNSPECIFIED Szikora, Istvan UNSPECIFIED UNSPECIFIED UNSPECIFIED Klisch, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbreteau, Denis UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmannspotter, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Januel, Anne-Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sychra, Vojtech UNSPECIFIED UNSPECIFIED UNSPECIFIED Strasilla, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Cognard, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonafe, Alain UNSPECIFIED UNSPECIFIED UNSPECIFIED Molyneux, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Byrne, James V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spelle, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-277809
DOI:	10.3171/2015.2.JNS142634
Journal or Publication Title:	J. Neurosurg.
Volume:	124
Number:	5
Page Range:	S. 1250 - 1257
Date:	2016
Publisher:	AMER ASSOC NEUROLOGICAL SURGEONS
Place of Publication:	ROLLING MEADOWS
ISSN:	1933-0693
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNRUPTURED INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; FLOW-DISRUPTION; COILING; TRIAL Multiple languages Clinical Neurology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27780