Universität zu Köln

Goede, Valentin, Bahlo, Jasmin, Chataline, Viktoria, Eichhorst, Barbara, Duerig, Jan, Stilgenbauer, Stephan, Kolb, Gerald, Honecker, Friedemann, Wedding, Ulrich and Hallek, Michael (2016). Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: Results of the CLL9 trial of the German CLL study group. Leuk. Lymphoma, 57 (4). S. 789 - 797. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

Multidimensional geriatric assessment (GA) has been demonstrated to predict outcomes in older patients with cancer. This study evaluated GA in a cohort of older patients with chronic lymphocytic leukemia (CLL). Seventy-five of 97 subjects with CLL who were enrolled in a clinical trial of the German CLL Study Group underwent GA prior to the start of study treatment (low-dose chemotherapy with fludarabine). GA included cumulative illness rating scale (CIRS), timed-up-and-go (TUG) test, dementia detection (DEMTECT) test and instrumental activities of daily living (IADL) index. There was little correlation between CIRS, TUG, DEMTECT or IADL results and treatment toxicity, feasibility or efficacy in this study. CIRS and IADL had no statistically significant impact on overall prognosis. However, under-performance in TUG or DEMTECT test was strongly associated with poor survival. The latter findings provide a rationale to further investigate geriatric assessment in CLL and in the context with other CLL treatments.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goede, Valentin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahlo, Jasmin UNSPECIFIED UNSPECIFIED UNSPECIFIED Chataline, Viktoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichhorst, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Duerig, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Stilgenbauer, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolb, Gerald UNSPECIFIED UNSPECIFIED UNSPECIFIED Honecker, Friedemann UNSPECIFIED UNSPECIFIED UNSPECIFIED Wedding, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-278945
DOI:	10.3109/10428194.2015.1091933
Journal or Publication Title:	Leuk. Lymphoma
Volume:	57
Number:	4
Page Range:	S. 789 - 797
Date:	2016
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREVIOUSLY UNTREATED PATIENTS; ILLNESS RATING-SCALE; OLDER PATIENTS; OPEN-LABEL; CHEMOTHERAPY TOXICITY; ELDERLY-PATIENTS; CANCER; CHLORAMBUCIL; RITUXIMAB; CYCLOPHOSPHAMIDE Multiple languages Oncology; Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27894