Universität zu Köln

Greer, Eric Lieberman, Becker, Ben, Latza, Christian, Antebi, Adam and Shi, Yang (2016). Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Cell Res., 26 (2). S. 229 - 239. LONDON: NATURE PUBLISHING GROUP. ISSN 1748-7838

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Abstract

Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Greer, Eric Lieberman UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Latza, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Yang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286143
DOI:	10.1038/cr.2015.148
Journal or Publication Title:	Cell Res.
Volume:	26
Number:	2
Page Range:	S. 229 - 239
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1748-7838
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE-SPAN; CAENORHABDITIS-ELEGANS; EPIGENETIC INHERITANCE; DAUER FORMATION; GERMLINE; TRIMETHYLATION; REPRODUCTION; IMMORTALITY; METHYLATION; FERTILITY Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28614