May, Margaret T., Gill, Michael J., Wittkop, Linda ORCID: 0000-0003-2403-0960, Klein, Marina, Sabin, Caroline ORCID: 0000-0001-5173-2760, Harrigan, P. Richard, Dunn, David, Vehreschild, Jorg Janne, Rubio, Rafael, Mocroft, Amanda, Cavassini, Matthias, Reiss, Peter, Monforte, Antonella D'Arminio, Zangerle, Robert, Ingle, Suzanne M., Hill, Teresa, Jose, Sophie, Sterne, Jonathan A. C., Boulle, Andrew ORCID: 0000-0002-7713-8062, Stephan, Christoph, Miro, Jose M., Cavassini, Matthias, Chene, Gene-Vieve, Costagliola, Dominique, Dabis, Francois, Monforte, Antonella D'Arminio, del Amo, Julia, Van Sighem, Ard, Vehreschild, Jorg, Gill, John, Guest, Jodie ORCID: 0000-0002-3650-3975, Haerry, David Hans-Ulrich, Hogg, Robert, Justice, Amy, Mocroft, Amanda, Obel, Niels, Crane, Heidi, Smith, Colette ORCID: 0000-0003-2847-3355, Reiss, Peter, Saag, Michael, Sterling, Tim, Teira, Ramon, Williams, Matthew, Zangerle, Robert, Sterne, Jonathan ORCID: 0000-0001-8496-6053, May, Margaret, Ingle, Suzanne, Trickey, Adam, Ainsworth, Jonathan, Anderson, Jane ORCID: 0000-0001-5294-8707, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Dunn, David, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Hay, Phillip, Gompels, Mark, Hill, Teresa, Johnson, Margaret, Jose, Sophie, Kegg, Stephen, Leen, Clifford, Mackie, Nicky, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Sabin, Caroline ORCID: 0000-0001-5173-2760, Sachikonye, Memory, Schwenk, Achim, Walsh, John, Thornton, Alicia, Huntington, Susie, Glabay, Adam, Orkin, Chloe, Garrett, Nigel, Lynch, Janet, Hand, James, de Souza, Carl, Fisher, Martin, Perry, Nicky, Tilbury, Stuart, Youssef, Elaney, Churchill, Duncan, Gazzard, Brian, Nelson, Mark, Waxman, Matthew, Asboe, David, Mandalia, Sundhiya, Anderson, Jane ORCID: 0000-0001-5294-8707, Munshi, Sajid, Awosika, Damilola, Post, Frank, Korat, Hardik, Taylor, Chris, Gleisner, Zachary, Ibrahim, Fowzia, Campbell, Lucy, Babiker, Abdel, Dunn, David, Glabay, Adam, Chadwick, David, Baillie, Kirsty, Cope, Emma, Gibney, Marie, Gibson, Jane, Gilson, Richard, Brima, Nataliya, Williams, Ian, Ainsworth, Jonathan, Schwenk, Achim, Miller, Sheila, Wood, Chris, Johnson, Margaret, Youle, Mike, Lampe, Fiona ORCID: 0000-0001-6851-5471, Smith, Colette ORCID: 0000-0003-2847-3355, Chaloner, Clinton, Hill, Teresa, Huntington, Susie, Jose, Sophie, Phillips, Andrew, Sabin, Caroline ORCID: 0000-0001-5173-2760, Thornton, Alicia, Walsh, John, Mackie, Nicky, Winston, Alan, Weber, Jonathan, Ramzan, Farhan, Carder, Mark, Leen, Clifford, Wilson, Alan, Morris, Sheila, Gompels, Mark, Allan, Sue, Palfreeman, Adrian, Moore, Anne, Fox, Lynn, Bojanowski, Josef, Lewszuk, Adam, Kegg, Stephen, Main, Paul, Mitchell, Dr, Hunter, Dr, Sachikonye, Memory, Hay, Phillip, Dhillon, Mandip, Martin, Fabiola, Douglas, Sarah and Russell-Sharp, Sarah (2016). Mortality of treated HIV-1 positive individuals according to viral subtype in Europe and Canada: collaborative cohort analysis. Aids, 30 (3). S. 503 - 514. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

Objectives:To estimate prognosis by viral subtype in HIV-1-infected individuals from start of antiretroviral therapy (ART) and after viral failure.Design:Collaborative analysis of data from eight European and three Canadian cohorts.Methods:Adults (N>20000) who started triple ART between 1996 and 2012 and had data on viral subtype were followed for mortality. We estimated crude and adjusted (for age, sex, regimen, CD4(+) cell count, and AIDS at baseline, period of starting ART, stratified by cohort, region of origin and risk group) mortality hazard ratios (MHR) by subtype. We estimated MHR subsequent to viral failure defined as two HIV-RNA measurements greater than 500 copies/ml after achieving viral suppression.Results:The most prevalent subtypes were B (15419; 74%), C (2091; 10%), CRF02AG (1057; 5%), A (873; 4%), CRF01AE (506; 2.4%), G (359; 1.7%), and D (232; 1.1%). Subtypes were strongly patterned by region of origin and risk group. During 104649 person-years of observation, 1172/20784 patients died. Compared with subtype B, mortality was higher for subtype A, but similar for all other subtypes. MHR for A versus B were 1.13 (95% confidence interval 0.85,1.50) when stratified by cohort, increased to 1.78 (1.27,2.51) on stratification by region and risk, and attenuated to 1.59 (1.14,2.23) on adjustment for covariates. MHR for A versus B was 2.65 (1.64,4.28) and 0.95 (0.57,1.57) for patients who started ART with CD4(+) cell count below, or more than, 100 cells/l, respectively. There was no difference in mortality between subtypes A, B and C after viral failure.Conclusion:Patients with subtype A had worse prognosis, an observation which may be confounded by socio-demographic factors. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
May, Margaret T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittkop, LindaUNSPECIFIEDorcid.org/0000-0003-2403-0960UNSPECIFIED
Klein, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabin, CarolineUNSPECIFIEDorcid.org/0000-0001-5173-2760UNSPECIFIED
Harrigan, P. RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunn, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Jorg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rubio, RafaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavassini, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiss, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monforte, Antonella D'ArminioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zangerle, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ingle, Suzanne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jose, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterne, Jonathan A. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boulle, AndrewUNSPECIFIEDorcid.org/0000-0002-7713-8062UNSPECIFIED
Stephan, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro, Jose M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavassini, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chene, Gene-VieveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costagliola, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dabis, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monforte, Antonella D'ArminioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Amo, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Sighem, ArdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guest, JodieUNSPECIFIEDorcid.org/0000-0002-3650-3975UNSPECIFIED
Haerry, David Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogg, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Justice, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obel, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crane, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, ColetteUNSPECIFIEDorcid.org/0000-0003-2847-3355UNSPECIFIED
Reiss, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saag, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterling, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teira, RamonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zangerle, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterne, JonathanUNSPECIFIEDorcid.org/0000-0001-8496-6053UNSPECIFIED
May, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ingle, SuzanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trickey, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ainsworth, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderson, JaneUNSPECIFIEDorcid.org/0000-0001-5294-8707UNSPECIFIED
Babiker, AbdelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chadwick, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delpech, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunn, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fisher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gazzard, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilson, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hay, PhillipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gompels, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jose, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kegg, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leen, CliffordUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mackie, NickyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orkin, ChloeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palfreeman, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pillay, DeenanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Post, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabin, CarolineUNSPECIFIEDorcid.org/0000-0001-5173-2760UNSPECIFIED
Sachikonye, MemoryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwenk, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thornton, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huntington, SusieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glabay, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orkin, ChloeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garrett, NigelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lynch, JanetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hand, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Souza, CarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fisher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perry, NickyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tilbury, StuartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Youssef, ElaneyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Churchill, DuncanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gazzard, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nelson, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waxman, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Asboe, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mandalia, SundhiyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderson, JaneUNSPECIFIEDorcid.org/0000-0001-5294-8707UNSPECIFIED
Munshi, SajidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Awosika, DamilolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Post, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korat, HardikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gleisner, ZacharyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ibrahim, FowziaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, LucyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Babiker, AbdelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunn, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glabay, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chadwick, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baillie, KirstyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cope, EmmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibney, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibson, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilson, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brima, NataliyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ainsworth, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwenk, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miller, SheilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Youle, MikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lampe, FionaUNSPECIFIEDorcid.org/0000-0001-6851-5471UNSPECIFIED
Smith, ColetteUNSPECIFIEDorcid.org/0000-0003-2847-3355UNSPECIFIED
Chaloner, ClintonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huntington, SusieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jose, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabin, CarolineUNSPECIFIEDorcid.org/0000-0001-5173-2760UNSPECIFIED
Thornton, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mackie, NickyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winston, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramzan, FarhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carder, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leen, CliffordUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, SheilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gompels, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allan, SueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palfreeman, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moore, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, LynnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojanowski, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewszuk, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kegg, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Main, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mitchell, DrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, DrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachikonye, MemoryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hay, PhillipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dhillon, MandipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, FabiolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Douglas, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell-Sharp, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-286932
DOI: 10.1097/QAD.0000000000000941
Journal or Publication Title: Aids
Volume: 30
Number: 3
Page Range: S. 503 - 514
Date: 2016
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1473-5571
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMBINATION ANTIRETROVIRAL THERAPY; T-CELL DECLINE; DISEASE PROGRESSION; IMMUNOLOGICAL RESPONSE; TYPE-1 SUBTYPES; NAIVE PATIENTS; IMPACT; DIVERSITY; INFECTIONS; RESISTANCEMultiple languages
Immunology; Infectious Diseases; VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28693

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