Universität zu Köln

Malzacher, Matthias ORCID: 0000-0001-8841-9284, Kalayciyan, Raffi, Konstandin, Simon, Haneder, Stefan and Schad, Lothar R. (2016). Sodium-23 MRI of whole spine at 3 Tesla using a 5-channel receive-only phased-array and a whole-body transmit resonator. Z. Med. Phys., 26 (1). S. 95 - 101. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 0939-3889

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Abstract

Sodium magnetic resonance imaging (Na-23 MRI) is a unique and non-invasive imaging technique which provides important information on cellular level about the tissue of the human body. Several applications for Na-23 MRI were investigated with regard to the examination of the tissue viability and functionality for example in the brain, the heart or the breast. The Na-23 MRI technique can also be integrated as a potential monitoring instrument after radio-therapy or chemotherapy. The main contribution in this work was the adaptation of Na-23 MRI for spine imaging, which can provide essential information on the integrity of the intervertebral disks with respect to the early detection of disk degeneration. In this work, a transmit-only receive-only dual resonator system was designed and developed to cover the whole human spine using Na-23 MRI and increase the receive sensitivity. The resonator system consisted of an already presented Na-23 whole-body resonator and a newly developed 5-channel receive-only phased-array. The resonator system was first validated using bench top and phantom measurements. A threefold SNR improvement at the depth of the spine (similar to 7 cm) over the whole-body resonator was achieved using the spine array. Na-23 MR measurements of the human spine using the transmit-only receive-only resonator system were performed on a healthy volunteer within an acquisition time of 10 minutes. A density adapted 3D radial sequence was chosen with 6 mm isotropic resolution, 49 ms repetition time and a short echo time of 540 mu s. Furthermore, it was possible to quantify the tissue sodium concentration in the intervertebral discs in the lumbar region (120 ms repetition time) using this setup.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Malzacher, Matthias UNSPECIFIED orcid.org/0000-0001-8841-9284 UNSPECIFIED Kalayciyan, Raffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Konstandin, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schad, Lothar R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-290347
DOI:	10.1016/j.zemedi.2015.03.008
Journal or Publication Title:	Z. Med. Phys.
Volume:	26
Number:	1
Page Range:	S. 95 - 101
Date:	2016
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	0939-3889
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TISSUE SODIUM CONCENTRATION; INTERVERTEBRAL-DISK; QUANTIFICATION Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/29034