Papazoglou, Anna, Soos, Julien, Lundt, Andreas, Wormuth, Carola, Ginde, Varun Raj, Mueller, Ralf, Henseler, Christina, Broich, Karl, Xie, Kan, Ehninger, Dan, Haenisch, Britta and Weiergraber, Marco (2016). Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer's Disease. Neural. Plast., 2016. LONDON: HINDAWI LTD. ISSN 1687-5443

Full text not available from this repository.

Abstract

Alzheimer's disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. Besides motor activity, EEG recordings were analyzed for electroencephalographic seizure activity and frequency characteristics using a Fast Fourier Transformation (FFT) based approach. Automatic seizure detection revealed severe electroencephalographic seizure activity in both M1 and CA1 deflection in APPswePS1dE9 mice with gender-specific characteristics. Frequency analysis of both surface and deep EEG recordings elicited complex age, gender, and activity dependent alterations in the theta and gamma range. Females displayed an antithetic decrease in theta (theta) and increase in gamma (theta) power at 18-19 weeks of age whereas related changes in males occurred earlier at 14 weeks of age. In females, theta (theta) and gamma (theta) power alterations predominated in the inactive state suggesting a reduction in atropine-sensitive type II theta in APPswePS1dE9 animals. Gender-specific central dysrhythmia and network alterations in APPswePS1dE9 point to a functional role in behavioral and cognitive deficits and might serve as early biomarkers for AD in the future.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Papazoglou, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soos, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lundt, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wormuth, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ginde, Varun RajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henseler, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broich, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xie, KanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehninger, DanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haenisch, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiergraber, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-293185
DOI: 10.1155/2016/7167358
Journal or Publication Title: Neural. Plast.
Volume: 2016
Date: 2016
Publisher: HINDAWI LTD
Place of Publication: LONDON
ISSN: 1687-5443
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
THETA RHYTHM HETEROGENEITY; MILD COGNITIVE IMPAIRMENT; BETA-AMYLOID PROTEIN; MOUSE MODEL; NETWORK OSCILLATIONS; INDUCED NEURODEGENERATION; TRANSGENIC MOUSE; SEX-DIFFERENCES; EEG; NEURONSMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/29318

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item