Universität zu Köln

Balkunde, Rachappa ORCID: 0000-0002-6059-9532, Deneer, Anna, Bechtel, Hanna, Zhang, Bipei, Herberth, Stefanie, Pesch, Martina, Jaegle, Benjamin, Fleck, Christian and Hulskamp, Martin (2020). Identification of the Trichome Patterning Core Network Using Data from Weak ttg1 Alleles to Constrain the Model Space. Cell Reports, 33 (11). CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

The regular distribution of trichomes on leaves in Arabidopsis is a well-understood model system for two-dimensional pattern formation. It involves more than 10 genes and is governed by two patterning principles, the activator-inhibitor (AI) and the activator-depletion (AD) mechanisms, though their relative contributions are unknown. The complexity of gene interactions, protein interactions, and intra- and intercellular mobility of proteins makes it very challenging to understand which aspects are relevant for pattern formation. In this study, we use global mathematical methods combined with a constraining of data to identify the structure of the underlying network. To constrain the model, we perform a genetic, cell biological, and biochemical study of weak ttg1 alleles. We find that the core of trichome patterning is a combination of AI and AD mechanisms differentiating between two pathways activating the long-range inhibitor CPC and the short-range inhibitor TRY.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balkunde, Rachappa UNSPECIFIED orcid.org/0000-0002-6059-9532 UNSPECIFIED Deneer, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechtel, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Bipei UNSPECIFIED UNSPECIFIED UNSPECIFIED Herberth, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pesch, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaegle, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fleck, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hulskamp, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-308024
DOI:	10.1016/j.celrep.2020.108497
Journal or Publication Title:	Cell Reports
Volume:	33
Number:	11
Date:	2020
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYB TRANSCRIPTION FACTORS; EPIDERMAL-CELL FATE; ARABIDOPSIS TRICHOME; FUNCTIONAL DIVERSITY; ROOT; DIFFERENTIATION; GENES; GL1; TRIPTYCHON; GLABRA3 Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30802