Universität zu Köln

Skowron, Margaretha A., Hiester, Andreas, Paffenholz, Pia, Nestler, Tim, Heidenreich, Axel, Albers, Peter and Nettersheim, Daniel . Current developments and treatment options in the management of growing teratoma syndrome. Onkologe. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

Background The diagnosis of growing teratoma syndrome (GTS) is complex and due to the small number of cases it is difficult to evaluate the treatment options. A better understanding of the development of GTS and sensitization to its paradoxical clinical presentation is crucial for a successful treatment strategy. Objectives The aim of this review is to summarize the current literature on the development of and treatment options for GTS. Based on this, a molecular model for the development of GTS is proposed and an evidence-based treatment strategy is recommended. Materials and methods A selective literature search was carried out via PubMed. Results GTS is characterized by proliferating metastatic postpubertal teratoma without further nonseminomatous components, despite decreasing or normalizing concentrations of the serum tumor markers human chorionic gonadotropin beta (beta-HCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH) during chemotherapy. Conclusion We postulate that during chemotherapy, embryonal carcinoma cells develop into a population of transiently amplifying cells that resemble the stem cell pool of a germ cell layer tissue. This population has the potential to self-renew or to differentiate into all three germ cell layers (mesoderm/endoderm/ectoderm), thereby promoting growth of a teratoma. Complete resection of the entire teratoma is therefore necessary. Due to the high incidence of concurrent resection of organs, teratoma resections should be performed in multidisciplinary and specialized centers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Skowron, Margaretha A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hiester, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestler, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Albers, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettersheim, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-308682
DOI:	10.1007/s00761-020-00886-4
Journal or Publication Title:	Onkologe
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GERM-CELL TUMORS; TERM-FOLLOW-UP; MALIGNANT-TRANSFORMATION; PROGNOSTIC-FACTORS; CANCER; HISTOLOGIES; THERAPY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/30868