Stenzinger, Albrecht, van Tilburg, Cornelis M., Tabatabai, Ghazaleh, Laenger, Florian, Graf, Norbert, Griesinger, Frank, Heukamp, Lukas C., Hummel, Michael, Klingebiel, Thomas, Hettmer, Simone, Vokuhl, Christian, Merkelbach-Bruse, Sabine, Overkamp, Friedrich, Reichardt, Peter, Scheer, Monika, Weichert, Wilko, Westphalen, C. Benedikt, Bokemeyer, Carsten, Ivanyi, Philipp, Loges, Sonja, Schirmacher, Peter, Woermann, Bernhard, Bielack, Stefan and Seufferlein, Thomas T. W. . Diagnosis and therapy of tumors with NTRK gene fusion. Pathologe. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1963

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Abstract

NTRK gene fusions are sporadic genetic alterations that can occur across tumor entities. Whereas they are quite rare in most solid tumors they are present at much higher frequencies in certain rare tumors such as infantile fibrosarcoma, congenital mesoblastic nephroma, secretory breast, or salivary gland carcinoma. NTRK gene fusions or TRK fusion proteins are considered strong oncogenic drivers. If NTRK gene fusions are detected, TRK inhibitors such as entrectinib and larotrectinib can be used regardless of the tumor entity. So far only larotrectinib is approved in the European Union. Both drugs have been shown to be effective and well tolerated in phase I and phase II studies. The low prevalence of TRK fusion-positive cancers poses challenges for diagnostic and clinical work-flows. On one hand, patients with NTRK gene fusions should be identified; on the other hand, epidemiological, histological, and resource-related aspects have to be taken into account. Based on these premises, we suggest a diagnostic algorithm for TRK fusion cancers and present current data on TRK inhibitors.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stenzinger, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Tilburg, Cornelis M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabatabai, GhazalehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laenger, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griesinger, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heukamp, Lukas C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hummel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingebiel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hettmer, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vokuhl, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merkelbach-Bruse, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Overkamp, FriedrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichardt, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weichert, WilkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westphalen, C. BenediktUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bokemeyer, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivanyi, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loges, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schirmacher, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woermann, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bielack, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seufferlein, Thomas T. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-310592
DOI: 10.1007/s00292-020-00864-y
Journal or Publication Title: Pathologe
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-1963
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POSITIVE SOLID TUMORS; PEDIATRIC-PATIENTS; KINASE INHIBITORS; LAROTRECTINIB; ALK; ADULT; RECOMMENDATIONS; ENTRECTINIB; LANDSCAPE; CANCERSMultiple languages
PathologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31059

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