Ruethrich, Maria Madeleine, Giessen-Jung, C., Borgmann, S., Classen, A. Y., Dolff, S., Gruener, B., Hanses, F., Isberner, N., Koehler, P., Lanznaster, J., Merle, U., Nadalin, S., Piepel, C., Schneider, J., Schons, M., Strauss, R., Tometten, L., Vehreschild, J. J., von Lilienfeld-Toal, M., Beutel, G. and Wille, K. . COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry. Ann. Hematol.. NEW YORK: SPRINGER. ISSN 1432-0584

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Abstract

Introduction Since the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients) registry to determine whether cancer patients are at higher risk. Patients and methods We retrospectively analyzed a cohort of 435 cancer patients and 2636 non-cancer patients with confirmed SARS-CoV-2 infection, enrolled between March 16 and August 31, 2020. Data on socio-demographics, comorbidities, cancer-related features and infection course were collected. Age-, sex- and comorbidity-adjusted analysis was performed. Primary endpoint was COVID-19-related mortality. Results In total, 435 cancer patients were included in our analysis. Commonest age category was 76-85 years (36.5%), and 40.5% were female. Solid tumors were seen in 59% and lymphoma and leukemia in 17.5% and 11% of patients. Of these, 54% had an active malignancy, and 22% had recently received anti-cancer treatments. At detection of SARS-CoV-2, the majority (62.5%) presented with mild symptoms. Progression to severe COVID-19 was seen in 55% and ICU admission in 27.5%. COVID-19-related mortality rate was 22.5%. Male sex, advanced age, and active malignancy were associated with higher death rates. Comparing cancer and non-cancer patients, age distribution and comorbidity differed significantly, as did mortality (14% vs 22.5%, p value < 0.001). After adjustments for other risk factors, mortality was comparable. Conclusion Comparing cancer and non-cancer patients, outcome of COVID-19 was comparable after adjusting for age, sex, and comorbidity. However, our results emphasize that cancer patients as a group are at higher risk due to advanced age and pre-existing conditions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ruethrich, Maria MadeleineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giessen-Jung, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgmann, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, A. Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolff, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruener, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanses, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isberner, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lanznaster, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merle, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nadalin, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piepel, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schons, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tometten, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, J. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Lilienfeld-Toal, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beutel, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wille, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-311951
DOI: 10.1007/s00277-020-04328-4
Journal or Publication Title: Ann. Hematol.
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-0584
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MORTALITYMultiple languages
HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31195

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