Incorvaia, Cristoforo ORCID: 0000-0002-3965-7988, Al-Ahmad, Mona, Ansotegui, Ignacio J., Arasi, Stefania, Bachert, Claus, Bos, Catherine, Bousquet, Jean, Bozek, Andrzej ORCID: 0000-0003-2263-2263, Caimmi, Davide, Calderon, Moises A., Casale, Thomas, Custovic, Adnan, De Blay, Frederic, Demoly, Pascal, Devillier, Philippe, Didier, Alain, Fiocchi, Alessandro, Fox, Adam T., Gevaert, Philippe ORCID: 0000-0002-1629-8468, Gomez, Maximiliano, Heffler, Enrico, Ilina, Natalia, Irani, Carla, Jutel, Marek, Karagiannis, Efstrathios, Klimek, Ludger, Kuna, Piotr, O'Hehir, Robin, Kurbacheva, Oxana, Matricardi, Paolo M., Morais-Almeida, Mario, Mosges, Ralph, Novak, Natalija, Okamoto, Yoshitaka, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Passalacqua, Giovanni, Pawankar, Ruby, Pfaar, Oliver, Schmid-Grendelmeier, Peter, Scurati, Silvia, Tortajada-Girbes, Miguel, Vidal, Carmen, Virchow, J. Christian, Wahn, Ulrich, Worm, Margitta, Zieglmayer, Petra and Canonica, Giorgio W. . Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model. Allergy. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to detect specific IgE to single-allergen molecules and to distinguish the causative molecules from those merely cross-reactive, pursuit of patient's treatable traits addressing genetic, phenotypic, and psychosocial features, and omics, such as proteomics, epi-genomics, metabolomics, and breathomics, to forecast patient's responsiveness to therapies, to detect biomarker and mediators, and to verify the disease control. This new approach has already improved the precision of allergy diagnosis and is likely to significantly increase, through the higher performance achieved with the personalized treatment, the effectiveness of allergen immunotherapy by enhancing its already known and unique characteristics of treatment that acts on the causes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Incorvaia, CristoforoUNSPECIFIEDorcid.org/0000-0002-3965-7988UNSPECIFIED
Al-Ahmad, MonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansotegui, Ignacio J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arasi, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bachert, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bos, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bousquet, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bozek, AndrzejUNSPECIFIEDorcid.org/0000-0003-2263-2263UNSPECIFIED
Caimmi, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calderon, Moises A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casale, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Custovic, AdnanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Blay, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demoly, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devillier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Didier, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiocchi, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, Adam T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gevaert, PhilippeUNSPECIFIEDorcid.org/0000-0002-1629-8468UNSPECIFIED
Gomez, MaximilianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heffler, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilina, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Irani, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jutel, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karagiannis, EfstrathiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, LudgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuna, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Hehir, RobinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurbacheva, OxanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matricardi, Paolo M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morais-Almeida, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, NatalijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamoto, YoshitakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papadopoulos, Nikolaos G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Hae-SimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Passalacqua, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pawankar, RubyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaar, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmid-Grendelmeier, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scurati, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tortajada-Girbes, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Virchow, J. ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahn, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worm, MargittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zieglmayer, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canonica, Giorgio W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-314725
DOI: 10.1111/all.14575
Journal or Publication Title: Allergy
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1398-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUBLINGUAL IMMUNOTHERAPY; MOLECULAR DIAGNOSIS; PRECISION MEDICINE; TREATABLE TRAITS; CONTROLLED-TRIAL; ASTHMA; EFFICACY; PHARMACOTHERAPY; PRESCRIPTION; PERFORMANCEMultiple languages
Allergy; ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31472

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