Universität zu Köln

Hoffmann, Manuela A., Buchholz, Hans-Georg, Wieler, Helmut J., Rosar, Florian, Miederer, Matthias, Fischer, Nicolas ORCID: 0000-0003-3113-6886 and Schreckenberger, Mathias (2020). Dual-Time Point [Ga-68]Ga-PSMA-11 PET/CT Hybrid Imaging for Staging and Restaging of Prostate Cancer. Cancers, 12 (10). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary Early diagnosis and tumor characterization of prostate cancer (PCa) are important for accurate treatment. [Ga-68]Ga-PSMA-11 PET/CT turns out to constitute a major step toward improved diagnostic procedures to detect primary, recurrent, and metastatic PCa. The aim of our study is to evaluate the effect of a second imaging modality for the staging and restaging of PCa by possibly detecting additional PCa lesions due to the well-known increase of PSMA uptake over time. There was a significant increase in tracer uptake on delayed images in comparison to early [Ga-68]Ga-PSMA-11 PET/CT in our study, but the lesion positivity rate was comparable. However, in a few individual cases, additional delayed scans provided an information advantage in PCa lesion detection. The findings of our study are likely to be of major interest to clinicians as well as to researchers defining the algorithms that are necessary to implement this promising method with its specific tracer into clinical routine. Routine [Ga-68]Ga-PSMA-11 PET/CT (one hour post-injection) has been shown to accurately detect prostate cancer (PCa) lesions. The goal of this study is to evaluate the benefit of a dual-time point imaging modality for the staging and restaging of PCa patients. Biphasic [Ga-68]Ga-PSMA-11 PET/CT of 233 patients, who underwent early and late scans (one/three hours post-injection), were retrospectively studied. Tumor uptake and biphasic lesion detection for 215 biochemically recurrent patients previously treated for localized PCa (prostatectomized patients (P-P)/irradiated patients (P-I) and 18 patients suspected of having primary PCa (P-T) were separately evaluated. Late [Ga-68]Ga-PSMA-11 PET/CT imaging detected 554 PCa lesions in 114 P-P patients, 187 PCa lesions in 33 P-I patients, and 47 PCa lesions in 13 P-T patients. Most patients (106+32 P-P/P-I, 13 P-T) showed no additional PCa lesions. However, 11 PSMA-avid lesions were only detected in delayed images, and 33 lesions were confirmed as malignant by a SUVmax increase. The mean SUVmax of pelvic lymph node metastases was 25% higher (p < 0.001) comparing early and late PET/CT. High positivity rates from routine [Ga-68]Ga-PSMA-11 PET/CT for the staging and restaging of PCa patients were demonstrated. There was no decisive influence of additional late imaging with PCa lesion detection on therapeutic decisions. However, in a few individual cases, additional delayed scans provided an information advantage in PCa lesion detection due to higher tracer uptake and improved contrast.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffmann, Manuela A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchholz, Hans-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieler, Helmut J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosar, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Miederer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Nicolas UNSPECIFIED orcid.org/0000-0003-3113-6886 UNSPECIFIED Schreckenberger, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-316525
DOI:	10.3390/cancers12102788
Journal or Publication Title:	Cancers
Volume:	12
Number:	10
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESTRO-SIOG GUIDELINES; GA-68-PSMA-11 HBED-CC; LYMPH-NODE; BIOCHEMICAL RECURRENCE; RADIATION-DOSIMETRY; MEMBRANE ANTIGEN; PRIMARY THERAPY; T PET/CT; PSMA; METASTASES Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31652