Universität zu Köln

Ubags, Niki D. J., Alcazar, Miguel A. Alejandre, Kallapur, Suhas G., Knapp, Sylvia ORCID: 0000-0001-9016-5244, Lanone, Sophie, Lloyd, Clare M., Morty, Rory E., Pattaroni, Celine, Reynaert, Niki L., Rottier, Robbert J., Smits, Hermelijn H., Piters, Wouter A. A. de Steenhuijsen, Strickland, Deborah H. and Collins, Jennifer J. P. (2020). Early origins of lung disease: towards an interdisciplinary approach. Eur. Respir. Rev., 29 (157). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1600-0617

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Abstract

The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar Early origins of lung disease: towards an interdisciplinary approach (Lisbon, Portugal, November 2019).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ubags, Niki D. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcazar, Miguel A. Alejandre UNSPECIFIED UNSPECIFIED UNSPECIFIED Kallapur, Suhas G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knapp, Sylvia UNSPECIFIED orcid.org/0000-0001-9016-5244 UNSPECIFIED Lanone, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lloyd, Clare M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morty, Rory E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pattaroni, Celine UNSPECIFIED UNSPECIFIED UNSPECIFIED Reynaert, Niki L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottier, Robbert J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smits, Hermelijn H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piters, Wouter A. A. de Steenhuijsen UNSPECIFIED UNSPECIFIED UNSPECIFIED Strickland, Deborah H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Collins, Jennifer J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-317876
DOI:	10.1183/16000617.0191-2020
Journal or Publication Title:	Eur. Respir. Rev.
Volume:	29
Number:	157
Date:	2020
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	1600-0617
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESENCHYMAL STROMAL CELLS; EARLY-LIFE EXPOSURES; LONG-TERM PULMONARY; A VIRUS-INFECTION; NEONATAL HYPEROXIA; ADULT MICE; BRONCHOPULMONARY DYSPLASIA; INCREASES SENSITIVITY; CYTOKINE PRODUCTION; IMMUNE DEVELOPMENT Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31787