Meier, Kolja, Merseburg, Andrea, Isbrandt, Dirk, Marguet, Stephan Lawrence and Morellini, Fabio ORCID: 0000-0002-5185-3850 (2020). Dentate Gyrus Sharp Waves, a Local Field Potential Correlate of Learning in the Dentate Gyrus of Mice. J. Neurosci., 40 (37). S. 7105 - 7119. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

The hippocampus plays an essential role in learning. Each of the three major hippocampal subfields, dentate gyrus (DG), CA3, and CA1, has a unique function in memory formation and consolidation, and also exhibit distinct local field potential (LFP) signatures during memory consolidation processes in non-rapid eye movement (NREM) sleep. The classic LFP events of the CA1 region, sharp-wave ripples (SWRs), are induced by CA3 activity and considered to be an electrophysiological biomarker for episodic memory. In LFP recordings along the dorsal CA1-DG axis from sleeping male mice, we detected and classified two types of LFP events in the DG: high-amplitude dentate spikes (DSs), and a novel event type whose current source density (CSD) signature resembled that seen during CA1 SWR, but which, most often, occurred independently of them. Because we hypothesize that this event type is similarly induced by CA3 activity, we refer to it as dentate sharp wave (DSW). We show that both DSWs and DSs differentially modulate the electrophysiological properties of SWR and multiunit activity (MUA). Following two hippocampus-dependent memory tasks, DSW occurrence rates, ripple frequencies, and ripple and sharp wave (SW) amplitudes were increased in both, while SWR occurrence rates in dorsal CA1 increased only after the spatial task. Our results suggest that DSWs, like SWRs, are induced by CA3 activity and that DSWs complement SWRs as a hippocampal LFP biomarker of memory consolidation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Meier, KoljaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merseburg, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isbrandt, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marguet, Stephan LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morellini, FabioUNSPECIFIEDorcid.org/0000-0002-5185-3850UNSPECIFIED
URN: urn:nbn:de:hbz:38-319468
DOI: 10.1523/JNEUROSCI.2275-19.2020
Journal or Publication Title: J. Neurosci.
Volume: 40
Number: 37
Page Range: S. 7105 - 7119
Date: 2020
Publisher: SOC NEUROSCIENCE
Place of Publication: WASHINGTON
ISSN: 1529-2401
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HIPPOCAMPAL RIPPLES; IN-VIVO; MEMORY; NETWORK; CA3; SLEEP; ORGANIZATION; PLASTICITY; SYSTEMS; BURSTSMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31946

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