Loupy, Alexandre, Haas, Mark, Roufosse, Candice ORCID: 0000-0002-6490-4290, Naesens, Maarten, Adam, Benjamin ORCID: 0000-0003-1908-1739, Afrouzian, Marjan, Akalin, Enver, Alachkar, Nada, Bagnasco, Serena, Becker, Jan U., Cornell, Lynn D., Clahsen-van Groningen, Marian C., Demetris, Anthony J., Dragun, Duska ORCID: 0000-0002-0310-9269, van Huyen, Jean-Paul Duong, Farris, Alton B., Fogo, Agnes B., Gibson, Ian W., Glotz, Denis, Gueguen, Juliette, Kikic, Zeljko, Kozakowski, Nicolas ORCID: 0000-0001-9180-620X, Kraus, Edward, Lefaucheur, Carmen, Liapis, Helen, Mannon, Roslyn B., Montgomery, Robert A., Nankivell, Brian J., Nickeleit, Volker, Nickerson, Peter, Rabant, Marion, Racusen, Lorraine, Randhawa, Parmjeet, Robin, Blaise ORCID: 0000-0001-7769-1418, Rosales, Ivy A., Sapir-Pichhadze, Ruth, Schinstock, Carrie A., Seron, Daniel, Singh, Harsharan K., Smith, Rex N., Stegall, Mark D., Zeevi, Adriana, Solez, Kim, Colvin, Robert B. and Mengel, Michael (2020). The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell- and antibody-mediated rejection. Am. J. Transplant., 20 (9). S. 2318 - 2332. HOBOKEN: WILEY. ISSN 1600-6143

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Abstract

The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell-mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing micro-vascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Loupy, AlexandreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roufosse, CandiceUNSPECIFIEDorcid.org/0000-0002-6490-4290UNSPECIFIED
Naesens, MaartenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adam, BenjaminUNSPECIFIEDorcid.org/0000-0003-1908-1739UNSPECIFIED
Afrouzian, MarjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akalin, EnverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alachkar, NadaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bagnasco, SerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, Jan U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornell, Lynn D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clahsen-van Groningen, Marian C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demetris, Anthony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dragun, DuskaUNSPECIFIEDorcid.org/0000-0002-0310-9269UNSPECIFIED
van Huyen, Jean-Paul DuongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farris, Alton B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fogo, Agnes B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibson, Ian W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glotz, DenisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gueguen, JulietteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kikic, ZeljkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozakowski, NicolasUNSPECIFIEDorcid.org/0000-0001-9180-620XUNSPECIFIED
Kraus, EdwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lefaucheur, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liapis, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mannon, Roslyn B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Robert A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nankivell, Brian J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickeleit, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickerson, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabant, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racusen, LorraineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Randhawa, ParmjeetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robin, BlaiseUNSPECIFIEDorcid.org/0000-0001-7769-1418UNSPECIFIED
Rosales, Ivy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sapir-Pichhadze, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schinstock, Carrie A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seron, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singh, Harsharan K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Rex N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stegall, Mark D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeevi, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Solez, KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colvin, Robert B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mengel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-320015
DOI: 10.1111/ajt.15898
Journal or Publication Title: Am. J. Transplant.
Volume: 20
Number: 9
Page Range: S. 2318 - 2332
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1600-6143
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLASSIFICATION; DEFINITIONS; PROSPECTSMultiple languages
Surgery; TransplantationMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32001

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