Universität zu Köln

Goergens, Christian, Guddat, Sven, Bosse, Christina, Knoop, Andre ORCID: 0000-0003-0040-8754, Geyer, Hans and Thevis, Mario (2020). Implementation of the HIF activator IOX-2 in routine doping controls - Pilot study data. Drug Test. Anal., 12 (11-12). S. 1614 - 1620. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

Early in 2020, racehorse doping cases revolved around the hypoxia-inducible factor (HIF) activator IOX-2. While the composition of IOX-2 has also been known and monitored in human doping controls for several years, the testing capability of routine sports drug testing methods was revisited for this newly surfaced doping agent. IOX-2 and the analytically well-established HIF activator roxadustat (FG-4592) share identical precursor/product ion pairs, enabling their co-detection in existing initial testing procedures in routine doping controls for the intact unconjugated analytes. In addition, hydroxylated IOX-2 and the corresponding glucuronic acid conjugates were identified as major metabolites in a microdose elimination study, contributing to enhanced initial testing and confirmation procedures.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goergens, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Guddat, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Bosse, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Knoop, Andre UNSPECIFIED orcid.org/0000-0003-0040-8754 UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-321967
DOI:	10.1002/dta.2914
Journal or Publication Title:	Drug Test. Anal.
Volume:	12
Number:	11-12
Page Range:	S. 1614 - 1620
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FG-4592 Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32196