Li, Ningfei ORCID: 0000-0003-3315-3591, Baldermann, Juan Carlos, Kibleur, Astrid, Treu, Svenja ORCID: 0000-0001-7920-4740, Akram, Harith ORCID: 0000-0002-2899-628X, Elias, Gavin J. B., Boutet, Alexandre ORCID: 0000-0001-6942-5195, Lozano, Andres M., Al-Fatly, Bassam ORCID: 0000-0003-0067-6177, Strange, Bryan, Barcia, Juan A., Zrinzo, Ludvic, Joyce, Eileen, Chabardes, Stephan, Visser-Vandewalle, Veerle, Polosan, Mircea, Kuehn, Jens, Kuehn, Andrea A. and Horn, Andreas ORCID: 0000-0002-0695-6025 (2020). A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder. Nat. Commun., 11 (1). BERLIN: NATURE RESEARCH. ISSN 2041-1723

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Abstract

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different targets may modulate the same neural network responsible for clinical improvement. We analyzed data from four cohorts of patients (N=50) that underwent DBS to the anterior limb of the internal capsule (ALIC), the nucleus accumbens or the subthalamic nucleus (STN). The same fiber bundle was associated with optimal clinical response in cohorts targeting either structure. This bundle connected frontal regions to the STN. When informing the tract target based on the first cohort, clinical improvements in the second could be significantly predicted, and vice versa. To further confirm results, clinical improvements in eight patients from a third center and six patients from a fourth center were significantly predicted based on their stimulation overlap with this tract. Our results show that connectivity-derived models may inform clinical improvements across DBS targets, surgeons and centers. The identified tract target is openly available in atlas form. Li et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Li, NingfeiUNSPECIFIEDorcid.org/0000-0003-3315-3591UNSPECIFIED
Baldermann, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kibleur, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treu, SvenjaUNSPECIFIEDorcid.org/0000-0001-7920-4740UNSPECIFIED
Akram, HarithUNSPECIFIEDorcid.org/0000-0002-2899-628XUNSPECIFIED
Elias, Gavin J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boutet, AlexandreUNSPECIFIEDorcid.org/0000-0001-6942-5195UNSPECIFIED
Lozano, Andres M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al-Fatly, BassamUNSPECIFIEDorcid.org/0000-0003-0067-6177UNSPECIFIED
Strange, BryanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barcia, Juan A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zrinzo, LudvicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joyce, EileenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chabardes, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polosan, MirceaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuehn, Andrea A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, AndreasUNSPECIFIEDorcid.org/0000-0002-0695-6025UNSPECIFIED
URN: urn:nbn:de:hbz:38-327000
DOI: 10.1038/s41467-020-16734-3
Journal or Publication Title: Nat. Commun.
Volume: 11
Number: 1
Date: 2020
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUBTHALAMIC NUCLEUS; ELECTRICAL-STIMULATION; CAPSULAR STIMULATION; BASAL GANGLIA; CONNECTIVITY; OUTCOMES; DISEASE; CORTEX; DBS; GPIMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32700

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