Universität zu Köln

Afifi, K., Bellanger, G., Buyck, P. J., Zuurbier, S. M., Esperon, C. G., Barboza, M. A., Costa, P., Escudero, I, Renard, D., Lemmens, R., Hinteregger, N., Fazekas, F., Jimenez Conde, J., Giralt-Steinhauer, E., Hiltunen, S., Arauz, A., Pezzini, A., Montaner, J., Putaala, J., Weimar, C., Schlamann, Marc, Gattringer, T., Tatlisumak, T., Coutinho, J. M., Demaerel, P. and Thijs, V (2020). Features of intracranial hemorrhage in cerebral venous thrombosis. J. Neurol., 267 (11). S. 3292 - 3299. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

Background Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. Aim To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. Methods We performed a retrospective analysis of an international, multicenter cohort of patients with confirmed cerebral venous thrombosis who underwent computed tomography within 2 weeks of symptom onset. Clinical and imaging features were compared between patients with and without intracranial hemorrhage. Clot burden was assessed by counting the number of thrombosed venous sinuses and veins on confirmatory imaging. Results We enrolled 260 patients from 10 institutions in Europe and Mexico. The mean age was 42 years and 74% were female. Intracranial hemorrhage was found in 102 (39%). Among them parenchymal hemorrhage occurred in 64 (63%), in addition, small juxta-cortical hemorrhage was found in 30 (29%), subarachnoid hemorrhage in 24 (24%) and subdural hemorrhage in 11 (11%). Multiple concomitant types of hemorrhage occurred in 23 (23%). Older age and superior sagittal thrombosis involvement were associated with presence of hemorrhage. The number of thrombosed venous sinuses was not associated with intracranial hemorrhage (median number IQRInterquartile ratio] of sinuses/veins involved with hemorrhage 2 (1-3) vs. 2 (1-3) without hemorrhage,p = 0.4). Conclusion The high rate of intracranial hemorrhage in cerebral venous thrombosis is not explained by widespread involvement of the venous sinuses. Superior sagittal sinus involvement is associated with higher bleeding risk.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Afifi, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bellanger, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buyck, P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zuurbier, S. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Esperon, C. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barboza, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Costa, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Escudero, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Renard, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemmens, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinteregger, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fazekas, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jimenez Conde, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giralt-Steinhauer, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hiltunen, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arauz, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pezzini, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Montaner, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Putaala, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weimar, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Gattringer, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tatlisumak, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coutinho, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Demaerel, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thijs, V UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-329374
DOI:	10.1007/s00415-020-10008-0
Journal or Publication Title:	J. Neurol.
Volume:	267
Number:	11
Page Range:	S. 3292 - 3299
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPERIOR SAGITTAL SINUS; SUBARACHNOID HEMORRHAGE; ANTICOAGULATION; OCCLUSION; PROGNOSIS; DISEASE; STROKE; VEIN Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32937