Pashayan, Nora ORCID: 0000-0003-0843-2468, Antoniou, Antonis C., Ivanus, Urska ORCID: 0000-0002-7909-522X, Esserman, Laura J., Easton, Douglas F., French, David, Sroczynski, Gaby, Hall, Per, Cuzick, Jack, Evans, D. Gareth, Simard, Jacques, Garcia-Closas, Montserrat, Schmutzler, Rita, Wegwarth, Odette, Pharoah, Paul, Moorthie, Sowmiya, De Montgolfier, Sandrine, Baron, Camille, Herceg, Zdenko, Turnbull, Clare, Balleyguier, Corinne, Rossi, Paolo Giorgi ORCID: 0000-0001-9703-2460, Wesseling, Jelle ORCID: 0000-0002-8940-2676, Ritchie, David ORCID: 0000-0003-4816-113X, Tischkowitz, Marc, Broeders, Mireille, Reisel, Dan ORCID: 0000-0001-9018-4621, Metspalu, Andres, Callender, Thomas, de Koning, Harry, Devilee, Peter, Delaloge, Suzette, Schmidt, Marjanka K. and Widschwendter, Martin ORCID: 0000-0002-7778-8380 (2020). Personalized early detection and prevention of breast cancer: ENVISION consensus statement. Nat. Rev. Clin. Oncol., 17 (11). S. 687 - 706. BERLIN: NATURE RESEARCH. ISSN 1759-4782

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Abstract

The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness-implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas. Risk-adapted approaches to breast cancer prevention and screening could potentially be more effective than universal approaches, which have important limitations. In this Consensus Statement, representatives of the European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. They also present the ENVISION recommendations on priorities for future research in each of these areas with the aim of stimulating and guiding risk-adapted breast cancer prevention and screening programmes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pashayan, NoraUNSPECIFIEDorcid.org/0000-0003-0843-2468UNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivanus, UrskaUNSPECIFIEDorcid.org/0000-0002-7909-522XUNSPECIFIED
Esserman, Laura J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
French, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sroczynski, GabyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hall, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuzick, JackUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Closas, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wegwarth, OdetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moorthie, SowmiyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Montgolfier, SandrineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baron, CamilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herceg, ZdenkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turnbull, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balleyguier, CorinneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossi, Paolo GiorgiUNSPECIFIEDorcid.org/0000-0001-9703-2460UNSPECIFIED
Wesseling, JelleUNSPECIFIEDorcid.org/0000-0002-8940-2676UNSPECIFIED
Ritchie, DavidUNSPECIFIEDorcid.org/0000-0003-4816-113XUNSPECIFIED
Tischkowitz, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broeders, MireilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reisel, DanUNSPECIFIEDorcid.org/0000-0001-9018-4621UNSPECIFIED
Metspalu, AndresUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Callender, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Koning, HarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delaloge, SuzetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Marjanka K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Widschwendter, MartinUNSPECIFIEDorcid.org/0000-0002-7778-8380UNSPECIFIED
URN: urn:nbn:de:hbz:38-329618
DOI: 10.1038/s41571-020-0388-9
Journal or Publication Title: Nat. Rev. Clin. Oncol.
Volume: 17
Number: 11
Page Range: S. 687 - 706
Date: 2020
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 1759-4782
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NIPPLE-SPARING MASTECTOMY; SURGICAL ADJUVANT BREAST; ISPOR TASK-FORCE; BODY-MASS INDEX; RISK-FACTORS; FOLLOW-UP; COLLABORATIVE REANALYSIS; HEALTH-PROFESSIONALS; SCREENING TRIALS; CLINICAL UTILITYMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32961

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