Jais, Alexander ORCID: 0000-0002-9897-4983, Paeger, Lars, Sotelo-Hitschfeld, Tamara, Bremser, Stephan, Prinzensteiner, Melanie, Klemm, Paul ORCID: 0000-0002-5985-1737, Mykytiuk, Vasyl ORCID: 0000-0001-9495-2093, Widdershooven, Pia J. M., Vesting, Anna Juliane, Grzelka, Katarzyna, Minere, Marielle, Cremer, Anna Lena, Xu, Jie, Korotkova, Tatiana, Lowell, Bradford B., Zeilhofer, Hanns Ulrich ORCID: 0000-0001-6954-4629, Backes, Heiko, Fenselau, Henning, Wunderlich, F. Thomas, Kloppenburg, Peter and Bruening, Jens C. (2020). PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron, 106 (6). S. 1009 - 1036. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC). PNOCARC neurons represent a previously unrecognized GABAergic population of ARC neurons distinct from well-defined feeding regulatory AgRP or POMC neurons. PNOCARC neurons arborize densely in the ARC and provide inhibitory synaptic input to nearby anorexigenic POMC neurons. Optogenetic activation of PNOCARC neurons in the ARC and their projections to the bed nucleus of the stria terminalis promotes feeding. Selective ablation of these cells promotes the activation of POMC neurons upon HFD exposure, reduces feeding, and protects from obesity, but it does not affect food intake or body weight under normal chow consumption. We characterize PNOCARC neurons as a novel ARC neuron population activated upon palatable food consumption to promote hyperphagia.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Jais, AlexanderUNSPECIFIEDorcid.org/0000-0002-9897-4983UNSPECIFIED
Paeger, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sotelo-Hitschfeld, TamaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bremser, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prinzensteiner, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klemm, PaulUNSPECIFIEDorcid.org/0000-0002-5985-1737UNSPECIFIED
Mykytiuk, VasylUNSPECIFIEDorcid.org/0000-0001-9495-2093UNSPECIFIED
Widdershooven, Pia J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesting, Anna JulianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grzelka, KatarzynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minere, MarielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cremer, Anna LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xu, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korotkova, TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lowell, Bradford B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeilhofer, Hanns UlrichUNSPECIFIEDorcid.org/0000-0001-6954-4629UNSPECIFIED
Backes, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fenselau, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wunderlich, F. ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kloppenburg, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruening, Jens C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-329738
DOI: 10.1016/j.neuron.2020.03.022
Journal or Publication Title: Neuron
Volume: 106
Number: 6
Page Range: S. 1009 - 1036
Date: 2020
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSLATIONAL PROFILING APPROACH; POMC NEURONS; NOCICEPTIN/ORPHANIN FQ; INTRINSIC EXCITABILITY; AGRP/NPY NEURONS; ARCUATE NUCLEUS; ENERGY-BALANCE; CALORIC-INTAKE; MESSENGER-RNA; FOOD-INTAKEMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32973

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