Andersen, Katrine B., Hansen, Allan K., Sommerauer, Michael, Fedorova, Tatyana D., Knudsen, Karoline, Vang, Kim, Van den Berge, Nathalie, Kinnerup, Martin, Nahimi, Adjmal, Pavese, Nicola ORCID: 0000-0002-6801-6194, Brooks, David J. and Borghammer, Per (2020). Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder - A PET study. Parkinsonism Relat. Disord., 75. S. 63 - 70. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Introduction: Noradrenergic denervation is thought to aggravate motor dysfunction in Parkinson's disease (PD). In a previous PET study with the norepinephrine transporter (NART) ligand C-11-MeNER, we detected reduced NART binding in primary sensorimotor cortex (M1S1) of PD patients. Idiopathic rapid-eye-movement sleep behaviour disorder (iRBD) is a phenotype of prodromal PD. Using C-11-MeNER PET, we investigated whether iRBD patients showed similar NART binding reductions in M1S1 cortex as PD patients. Additionally, we investigated whether C-11-MeNER binding and loss of nigrostriatal dopamine storage capacity measured with F-18-DOPA PET were correlated. Methods: 17 iRBD patients, 16 PD patients with (PDRBD+) and 14 without RBD (PDRBD-), and 25 control subjects underwent C-11-MeNER PET. iRBD patients also had F-18-DOPA PET. Volume-of-interest analyses and voxel-level statistical parametric mapping were performed. Results: Partial-volume corrected C-11-MeNER binding potential (BPND) values in M1S1 differed across the groups (P = 0.022) with the iRBD and PDRBD+ groups showing significant reductions (controls vs. iRBD P = 0.007; control vs. PDRBD+ P = 0.008). Voxel-wise comparisons confirmed reductions of M1S1 C-11-MeNER binding in PD and iRBD patients. Significant correlation was seen between putaminal F-18-DOPA uptake and thalamic C-11-MeNER binding in iRBD patients (r(2) = 0.343, P = 0.013). Conclusions: This study found altered noradrenergic neurotransmission in the M1S1 cortex of iRBD patients. The observed reduction of M1S1 C-11-MeNER binding in iRBD may represent noradrenergic terminal degeneration or physiological down-regulation of NARTs in this prodromal phenotype of PD. The correlation between thalamic C-11-MeNER binding and putaminal F-18-DOPA binding suggests that these neurotransmitter systems degenerate in parallel in the iRBD phenotype of prodromal PD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Andersen, Katrine B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, Allan K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sommerauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fedorova, Tatyana D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knudsen, KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vang, KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van den Berge, NathalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kinnerup, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nahimi, AdjmalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavese, NicolaUNSPECIFIEDorcid.org/0000-0002-6801-6194UNSPECIFIED
Brooks, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borghammer, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-331110
DOI: 10.1016/j.parkreldis.2020.05.013
Journal or Publication Title: Parkinsonism Relat. Disord.
Volume: 75
Page Range: S. 63 - 70
Date: 2020
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1873-5126
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PARKINSONS-DISEASE; COERULEUS/SUBCOERULEUS COMPLEX; SUBSTANTIA-NIGRA; DOPAMINE; MOTOR; NOREPINEPHRINE; NORADRENALINE; DEFICITS; THERAPYMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33111

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