Enders, Philip ORCID: 0000-0002-9527-4957, Longo, Valentina, Adler, Werner, Horstmann, Jens, Schaub, Friederike, Dietlein, Thomas, Cursiefen, Claus and Heindl, Ludwig M. (2020). Analysis of peripapillary vessel density and Bruch's membrane opening-based neuroretinal rim parameters in glaucoma using OCT and OCT-angiography. Eye, 34 (6). S. 1086 - 1094. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5454

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Abstract

Purpose To compare peripapillary vessel density (VD) measured by spectral domain optical coherence tomography angiography (SD-OCT-A) with morphometric parameters assessing the neuroretinal rim based on Bruch's membrane opening (BMO) by spectral domain optical coherence tomography (SD-OCT) in glaucoma. Methods In this non-interventional cohort study, 50 eyes of 25 consecutively enrolled patients with diagnosis of glaucoma underwent SD-OCT and SD-OCT-A imaging of the optic nerve head (ONH). BMO minimum rim width (BMO-MRW) and area (BMO-MRA) as well as peripapillary retinal nerve fiber layer (RNFL) thickness were compared to peripapillary VD in the RNFL layer around the ONH. Results Mean BMO-MRW was 221.46 +/- 81.5 mu m, mean BMO-MRA was 1.05 +/- 0.04 mm(2), mean RNFL thickness was 72.46 +/- 23.16 mu m, and mean VD was 43.8 +/- 11.4%. VD was significantly lower when morphometric parameters had lower thickness values (p < 0.01). Correlation coefficients and their 95%- confidence intervals (95%-CI) with VD were r = 0.53 (95%-CI: 0.21-0.77) for BMO-MRW, r = 0.55 (95%-CI: 0.21-0.77) for BMO-MRA, and r = 0.57 (95%-CI: 0.13-0.73) for RNFL thickness. Intra-individual VD in both eyes correlated with r = 0.72 (p < 0.001), mean VD was comparable (p = 0.6). Eyes with high global RNFL thickness (>90 mu m) showed less VD variance (sigma(2) = 48.1) compared to eyes with highly reduced RNFL thickness (<65 mu m; sigma(2) = 82.0). Best corrected visual acuity, perimetric mean defect, and PSD correlated significantly with VD (95%-CI: -0.66 to -0.10, 0.16 to 0.6, and -0.65 to -0.02, respectively). Conclusions Peripapillary vessel density measured by SD-OCT angiography correlates significantly with Bruch's membrane opening-based parameters measured by SD-OCT in glaucoma patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Enders, PhilipUNSPECIFIEDorcid.org/0000-0002-9527-4957UNSPECIFIED
Longo, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adler, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horstmann, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaub, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietlein, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl, Ludwig M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-332189
DOI: 10.1038/s41433-019-0631-8
Journal or Publication Title: Eye
Volume: 34
Number: 6
Page Range: S. 1086 - 1094
Date: 2020
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5454
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTRAOCULAR-PRESSURE MEASUREMENT; OUTFLOW; NERVE; ANGLEMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33218

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