Velickovic, Vladica M., Chadwick, Paul, Rippon, Mark G., Ilic, Ivana, McGlone, Emma Rose, Gebreslassie, Mihretab, Csernus, Mariann, Streit, Iris, Bordeanu, Adrian, Kasper, Daniela, Linder, Jorg and Smola, Hans (2020). Cost-effectiveness of superabsorbent wound dressing versus standard of care in patients with moderate-to-highly exuding leg ulcers. J. Wound Care, 29 (4). S. 235 - 246. LONDON: MA HEALTHCARE LTD. ISSN 2062-2916

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Abstract

Objective: To determine the cost-effectiveness/utility of a superabsorbent wound dressing (Zetuvit Plus Silicone) versus the current standard of care (SoC) dressings, from the NHS perspective in England, in patients with moderate-to-high exudating leg ulcers. Method: A model-based economic evaluation was conducted to analyse the cost-effectiveness/utility of a new intervention. We used a microsimulation state-transition model with a time horizon of six months and a cycle length of one week. The model uses a combination of incidence base and risk prediction approach to inform transition probabilities. All clinical efficiency, health-related quality of life (HRQoL), cost and resource use inputs were informed by conducting a systematic review of UK specific literature. Results: Treatment with the superabsorbent dressing leads to a total expected cost per patient for a six month period of 2887 pound, associated with 15.933 expected quality adjusted life weeks and 10.9% healing rate. When treated with SoC, the total expected cost per patient for a six month period is 3109 pound, 15.852 expected quality adjusted life weeks and 8% healing rate. Therefore, the superabsorbent dressing leads to an increase in quality-adjusted life weeks, an increase in healing rate by 2.9% and a cost-saving of 222 pound per single average patient over six months. Results of several scenario analyses, one-way deterministic sensitivity analysis, and probabilistic sensitivity analysis confirmed the robustness of base-case results. The probabilistic analysis confirmed that, in any combination of variable values, the superabsorbent dressing leads to cost saving results. Conclusion: According to the model prediction, the superabsorbent dressing leads to an increase in health benefits and a decrease in associated costs of treatment. Declaration of interest: Vladica M. Velickovic, Streit Iris, Adriana Bordeanu, Daniela Kaspar, Jorg Linder, and Hans Smola are full-time employees of the Hartmann Group.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Velickovic, Vladica M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chadwick, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rippon, Mark G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilic, IvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGlone, Emma RoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gebreslassie, MihretabUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Csernus, MariannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Streit, IrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bordeanu, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasper, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linder, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smola, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-339249
Journal or Publication Title: J. Wound Care
Volume: 29
Number: 4
Page Range: S. 235 - 246
Date: 2020
Publisher: MA HEALTHCARE LTD
Place of Publication: LONDON
ISSN: 2062-2916
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIRECTED ACYCLIC GRAPHS; REAL-WORLD DATA; TASK-FORCE; ECONOMIC-EVALUATION; IWGDF GUIDANCE; ISPOR; DATABASE; DELIVERY; MODELS; VALIDATIONMultiple languages
DermatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33924

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