Scheer, Monika, Blank, Bernd, Bauer, Sebastian ORCID: 0000-0001-5949-8120, Vokuhl, Christian, Stegmaier, Sabine, Feuchtgruber, Simone, Henssen, Anton, Sparber-Sauer, Monika, Eggert, Angelika ORCID: 0000-0003-3476-8184, Handgretinger, Ruppert, Pekrun, Arnulf, Rossig, Claudia, Rutkowski, Stefan, Schlegel, Paul-Gerhardt, Schrappe, Martin, Simon, Thorsten, Kazanowska, Bernarda, Niggli, Felix, Ladenstein, Ruth, Ljungman, Gustaf ORCID: 0000-0002-4949-2494, Jahnukainen, Kirsi, Fuchs, Joerg, Bielack, Stefan S., Koscielniak, Ewa and Klingebiel, Thomas (2020). Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS). J. Cancer Res. Clin. Oncol., 146 (4). S. 953 - 961. NEW YORK: SPRINGER. ISSN 1432-1335

Full text not available from this repository.

Abstract

Background Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown. Methods SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test. Results The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896). Conclusions The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients. Discussion The causes for these variations require further exploration.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Scheer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blank, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, SebastianUNSPECIFIEDorcid.org/0000-0001-5949-8120UNSPECIFIED
Vokuhl, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stegmaier, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feuchtgruber, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henssen, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sparber-Sauer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eggert, AngelikaUNSPECIFIEDorcid.org/0000-0003-3476-8184UNSPECIFIED
Handgretinger, RuppertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pekrun, ArnulfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossig, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutkowski, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlegel, Paul-GerhardtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrappe, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kazanowska, BernardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niggli, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ladenstein, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ljungman, GustafUNSPECIFIEDorcid.org/0000-0002-4949-2494UNSPECIFIED
Jahnukainen, KirsiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bielack, Stefan S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koscielniak, EwaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingebiel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-339640
DOI: 10.1007/s00432-019-03121-9
Journal or Publication Title: J. Cancer Res. Clin. Oncol.
Volume: 146
Number: 4
Page Range: S. 953 - 961
Date: 2020
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1335
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SOFT-TISSUE SARCOMA; SSX FUSION TYPE; PROGNOSTIC-FACTORS; CHROMOSOME INSTABILITY; MULTIVARIATE-ANALYSIS; CHILDHOOD; ADOLESCENCE; CHILDREN; MULTICENTER; GERMANMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33964

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item