Cohen-Dvashi, Hadas, Zehner, Matthias, Ehrhardt, Stefanie, Katz, Michael, Elad, Nadav, Klein, Florian and Diskin, Ron (2020). Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27 (3). S. 418 - 432. CAMBRIDGE: CELL PRESS. ISSN 1934-6069

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Abstract

Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V(H)3-15/V(lambda)1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three V(H)3-15/V(lambda)1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the V(H)3-15/V(lambda)1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of V(H)3-15/V(lambda)1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Cohen-Dvashi, HadasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zehner, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehrhardt, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elad, NadavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diskin, RonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-341195
DOI: 10.1016/j.chom.2020.01.007
Journal or Publication Title: Cell Host Microbe
Volume: 27
Number: 3
Page Range: S. 418 - 432
Date: 2020
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1934-6069
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
POTENT NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; CONTROLLED-TRIAL; VACCINE; SEQUENCE; PROTECTION; INFECTION; DISEASEMultiple languages
Microbiology; Parasitology; VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34119

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