Stemler, Jannik ORCID: 0000-0001-9152-2469, Bruns, Caroline, Mellinghoff, Sibylle C., Alakel, Nael ORCID: 0000-0003-3669-5564, Akan, Hamdi, Ananda-Rajah, Michelle ORCID: 0000-0001-7164-3108, Auberger, Jutta, Bojko, Peter, Chandrasekar, Pranatharthi H., Chayakulkeeree, Methee ORCID: 0000-0002-4582-4914, Cozzi, Jose A., de Kort, Elizabeth A., Groll, Andreas H., Heath, Christopher H., Henze, Larissa, Hernandez Jimenez, Marcos, Kanj, Souha S., Khanna, Nina ORCID: 0000-0002-2642-419X, Koldehoff, Michael ORCID: 0000-0002-8738-5884, Lee, Dong-Gun, Mager, Alina, Marchesi, Francesco ORCID: 0000-0001-6353-2272, Martino-Bufarull, Rodrigo, Nucci, Marcio ORCID: 0000-0003-4867-0014, Oksi, Jarmo, Pagano, Livio, Phillips, Bob ORCID: 0000-0002-4938-9673, Prattes, Juergen ORCID: 0000-0001-5751-9311, Pyrpasopoulou, Athina, Rabitsch, Werner, Schalk, Enrico ORCID: 0000-0003-1892-5098, Schmidt-Hieber, Martin, Sidharthan, Neeraj ORCID: 0000-0002-0115-8104, Soler-Palacin, Pere, Stern, Anat ORCID: 0000-0002-8659-8108, Weinbergerova, Barbora, El Zakhem, Aline, Cornely, Oliver A. and Koehler, Philipp ORCID: 0000-0002-7386-7495 (2020). Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients. J. Fungi, 6 (1). BASEL: MDPI. ISSN 2309-608X

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Abstract

Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stemler, JannikUNSPECIFIEDorcid.org/0000-0001-9152-2469UNSPECIFIED
Bruns, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mellinghoff, Sibylle C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alakel, NaelUNSPECIFIEDorcid.org/0000-0003-3669-5564UNSPECIFIED
Akan, HamdiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ananda-Rajah, MichelleUNSPECIFIEDorcid.org/0000-0001-7164-3108UNSPECIFIED
Auberger, JuttaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojko, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chandrasekar, Pranatharthi H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chayakulkeeree, MetheeUNSPECIFIEDorcid.org/0000-0002-4582-4914UNSPECIFIED
Cozzi, Jose A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Kort, Elizabeth A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groll, Andreas H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heath, Christopher H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henze, LarissaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hernandez Jimenez, MarcosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanj, Souha S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khanna, NinaUNSPECIFIEDorcid.org/0000-0002-2642-419XUNSPECIFIED
Koldehoff, MichaelUNSPECIFIEDorcid.org/0000-0002-8738-5884UNSPECIFIED
Lee, Dong-GunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mager, AlinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchesi, FrancescoUNSPECIFIEDorcid.org/0000-0001-6353-2272UNSPECIFIED
Martino-Bufarull, RodrigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nucci, MarcioUNSPECIFIEDorcid.org/0000-0003-4867-0014UNSPECIFIED
Oksi, JarmoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, BobUNSPECIFIEDorcid.org/0000-0002-4938-9673UNSPECIFIED
Prattes, JuergenUNSPECIFIEDorcid.org/0000-0001-5751-9311UNSPECIFIED
Pyrpasopoulou, AthinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabitsch, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schalk, EnricoUNSPECIFIEDorcid.org/0000-0003-1892-5098UNSPECIFIED
Schmidt-Hieber, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sidharthan, NeerajUNSPECIFIEDorcid.org/0000-0002-0115-8104UNSPECIFIED
Soler-Palacin, PereUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stern, AnatUNSPECIFIEDorcid.org/0000-0002-8659-8108UNSPECIFIED
Weinbergerova, BarboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El Zakhem, AlineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDorcid.org/0000-0002-7386-7495UNSPECIFIED
URN: urn:nbn:de:hbz:38-342078
DOI: 10.3390/jof6010036
Journal or Publication Title: J. Fungi
Volume: 6
Number: 1
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2309-608X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INVASIVE PULMONARY ASPERGILLOSIS; FUNGAL-INFECTIONS; EPIDEMIOLOGY; MALIGNANCIES; DIAGNOSIS; MANAGEMENT; LEUKEMIA; DISEASESMultiple languages
Microbiology; MycologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34207

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