Universität zu Köln

van Schie, Morten M. C. H., Kaczmarek, Alexander T., Tieves, Florian, Gomez de Santos, Patricia, Paul, Caroline E., Arends, Isabel W. C. E., Alcalde, Miguel, Schwarz, Guenter ORCID: 0000-0002-2118-9338 and Hollmann, Frank (2020). Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase-Catalysed In Situ Generation of H2O2. ChemCatChem, 12 (12). S. 3186 - 3190. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1867-3899

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Abstract

H2O2 can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enantio- and regio-selectivities hard to attain with classical chemical methods. The sensitivity of most peroxygenases towards H2O2, however, requires this oxidant to be generated in situ. Here, we suggest the application of (modified) sulfite oxidases to couple the oxidation of sulfites to the reduction of oxygen. This enables us to use calcium sulfite, an industrial waste product from scrubbing flue gases, as an electron donor to reduce oxygen. This will supply the required peroxide in a controlled manner and enables us to perform these challenging reactions at the expense of simple salts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Schie, Morten M. C. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaczmarek, Alexander T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tieves, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gomez de Santos, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Paul, Caroline E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arends, Isabel W. C. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcalde, Miguel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Guenter UNSPECIFIED orcid.org/0000-0002-2118-9338 UNSPECIFIED Hollmann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-344721
DOI:	10.1002/cctc.201902297
Journal or Publication Title:	ChemCatChem
Volume:	12
Number:	12
Page Range:	S. 3186 - 3190
Date:	2020
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1867-3899
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VANADIUM CHLOROPEROXIDASE; OXIDATION; COMBINATION; PROVIDES Multiple languages Chemistry, Physical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/34472