Automated Meningioma Segmentation in Multiparametric MRI Comparable Effectiveness of a Deep Learning Model and Manual Segmentation

Laukamp, Kai Roman ORCID: 0000-0002-5600-5914, Pennig, Lenhard, Thiele, Frank, Reimer, Robert, Goertz, Lukas, Shakirin, Georgy, Zopfs, David ORCID: 0000-0001-9978-7453, Timmer, Marco, Perkuhn, Michael and Borggrefe, Jan ORCID: 0000-0003-2908-7560 . Automated Meningioma Segmentation in Multiparametric MRI Comparable Effectiveness of a Deep Learning Model and Manual Segmentation. Clin. Neuroradiol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1869-1447

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DOI:10.1007/s00062-020-00884-4

Abstract

Purpose Volumetric assessment of meningiomas represents a valuable tool for treatment planning and evaluation of tumor growth as it enables a more precise assessment of tumor size than conventional diameter methods. This study established a dedicated meningioma deep learning model based on routine magnetic resonance imaging (MRI) data and evaluated its performance for automated tumor segmentation. Methods The MRI datasets included T1-weighted/T2-weighted, T1-weighted contrast-enhanced (T1CE) and FLAIR of 126 patients with intracranial meningiomas (grade I: 97, grade II: 29). For automated segmentation, an established deep learning model architecture (3D deep convolutional neural network, DeepMedic, BioMedIA) operating on all four MR sequences was used. Segmentation included the following two components: (i) contrast-enhancing tumor volume in T1CE and (ii) total lesion volume (union of lesion volume in T1CE and FLAIR, including solid tumor parts and surrounding edema). Preprocessing of imaging data included registration, skull stripping, resampling, and normalization. After training of the deep learning model using manual segmentations by 2 independent readers from 70 patients (training group), the algorithm was evaluated on 56 patients (validation group) by comparing automated to ground truth manual segmentations, which were performed by 2 experienced readers in consensus. Results Of the 56 meningiomas in the validation group 55 were detected by the deep learning model. In these patients the comparison of the deep learning model and manual segmentations revealed average dice coefficients of 0.91x202f;+/- 0.08 for contrast-enhancing tumor volume and 0.82x202f;+/- 0.12 for total lesion volume. In the training group, interreader variabilities of the 2 manual readers were 0.92x202f;+/- 0.07 for contrast-enhancing tumor and 0.88x202f;+/- 0.05 for total lesion volume. Conclusion Deep learning-based automated segmentation yielded high segmentation accuracy, comparable to manual interreader variability.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Laukamp, Kai Roman	UNSPECIFIED	orcid.org/0000-0002-5600-5914	UNSPECIFIED
Pennig, Lenhard	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Thiele, Frank	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Reimer, Robert	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Goertz, Lukas	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Shakirin, Georgy	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Zopfs, David	UNSPECIFIED	orcid.org/0000-0001-9978-7453	UNSPECIFIED
Timmer, Marco	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Perkuhn, Michael	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Borggrefe, Jan	UNSPECIFIED	orcid.org/0000-0003-2908-7560	UNSPECIFIED