Lienemann, Philipp S., Vallmajo-Martin, Queralt ORCID: 0000-0002-2352-7177, Papageorgiou, Panagiota, Blache, Ulrich, Metzger, Stephanie, Kivelio, Anna-Sofia, Milleret, Vincent, Sala, Ana, Hoehnel, Sylke, Roch, Aline, Reuten, Raphael ORCID: 0000-0002-9434-4108, Koch, Manuel, Naveiras, Olaia ORCID: 0000-0003-3434-0022, Weber, Franz E. ORCID: 0000-0003-1670-2296, Weber, Wilfried ORCID: 0000-0003-4340-4446, Lutolf, Matthias P. and Ehrbar, Martin ORCID: 0000-0003-2707-4870 (2020). Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment. Adv. Sci., 7 (7). HOBOKEN: WILEY. ISSN 2198-3844

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Abstract

The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mobilizing healing-associated mesenchymal progenitor cells (MPCs). Smart synthetic hydrogels are used to trap and study endogenous MPCs trafficking to bone defects. Hydrogel-trapped and prospectively isolated MPCs differentiate into multiple lineages in vitro and form bone in vivo. In vitro screenings reveal that platelet-derived growth factor BB (PDGF-BB) strongly recruits prospective MPCs making it a promising candidate for the engineering of hydrogels that enrich endogenous MPCs in vivo. However, PDGF-BB inhibits BMP-2-mediated osteogenesis both in vitro and in vivo. In contrast, smart two-way dynamic release hydrogels with fast-release of PDGF-BB and sustained delivery of BMP-2 beneficially promote the healing of bone defects. Collectively, it is shown that modulating the dynamics of endogenous progenitor cells in vivo by smart synthetic hydrogels significantly improves bone healing and holds great potential for other advanced applications in regenerative medicine.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lienemann, Philipp S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vallmajo-Martin, QueraltUNSPECIFIEDorcid.org/0000-0002-2352-7177UNSPECIFIED
Papageorgiou, PanagiotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blache, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kivelio, Anna-SofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milleret, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sala, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoehnel, SylkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roch, AlineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuten, RaphaelUNSPECIFIEDorcid.org/0000-0002-9434-4108UNSPECIFIED
Koch, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naveiras, OlaiaUNSPECIFIEDorcid.org/0000-0003-3434-0022UNSPECIFIED
Weber, Franz E.UNSPECIFIEDorcid.org/0000-0003-1670-2296UNSPECIFIED
Weber, WilfriedUNSPECIFIEDorcid.org/0000-0003-4340-4446UNSPECIFIED
Lutolf, Matthias P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehrbar, MartinUNSPECIFIEDorcid.org/0000-0003-2707-4870UNSPECIFIED
URN: urn:nbn:de:hbz:38-345434
DOI: 10.1002/advs.201903395
Journal or Publication Title: Adv. Sci.
Volume: 7
Number: 7
Date: 2020
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2198-3844
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEM-CELLS; IN-VITRO; OSTEOGENIC DIFFERENTIATION; GROWTH-FACTORS; MARROW; DELIVERY; MIGRATION; BMP-2; REPAIR; NICHEMultiple languages
Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34543

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