Universität zu Köln

He, Jianzheng, Hommen, Franziska, Lauer, Nina, Balmert, Sophia and Scholz, Henrike (2020). Serotonin transporter dependent modulation of food-seeking behavior. PLoS One, 15 (1). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

The olfactory pathway integrates the odor information required to generate correct behavioral responses. To address how changes of serotonin signaling in two contralaterally projecting, serotonin-immunoreactive deutocerebral neurons impacts key odorant attraction in Drosophila melanogaster, we selectively alter serotonin signaling using the serotonin transporter with mutated serotonin binding sites in these neurons and analyzed the consequence on odorant-guided food seeking. The expression of the mutated serotonin transporter selectively changed the odorant attraction in an odorant-specific manner. The shift in attraction was not influenced by more up-stream serotonergic mechanisms mediating behavioral inhibition. The expression of the mutated serotonin transporter in CSD neurons did not influence other behaviors associated with food seeking such as olfactory learning and memory or food consumption. We provide evidence that the change in the attraction by serotonin transporter function might be achieved by increased serotonin signaling and by different serotonin receptors. The 5-HT1B receptor positively regulated the attraction to low and negatively regulated the attraction to high concentrations of acetic acid. In contrast, 5-HT1A and 5-HT2A receptors negatively regulated the attraction in projection neurons to high acetic acid concentrations. These results provide insights into how serotonin signaling in two serotonergic neurons selectively regulates the behavioral response to key odorants during food seeking.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code He, Jianzheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Hommen, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Lauer, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Balmert, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-348281
DOI:	10.1371/journal.pone.0227554
Journal or Publication Title:	PLoS One
Volume:	15
Number:	1
Date:	2020
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTENNAL LOBE; OLFACTORY INFORMATION; DROSOPHILA; NEURONS; EXPRESSION; CONNECTIVITY; ARCHITECTURE; GLOMERULI; DOPAMINE; ETHANOL Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34828