Taheri, Hadiseh, Unal, Mehmet Altay, Sevim, Melike, Gurcan, Cansu, Ekim, Okan, Ceylan, Ahmet, Syrgiannis, Zois, Christoforidis, Konstantinos C., Bosi, Susanna, Ozgenc, Ozge, Gomez, Manuel Jose, Turktas Erken, Mine, Soydal, Cigdem ORCID: 0000-0002-6199-8551, Eroglu, Zafer, Bitirim, Ceylan Verda, Cagin, Umut, Ari, Fikret, Ozen, Asuman, Kucuk, Ozlem, Delogu, Lucia Gemma ORCID: 0000-0002-2329-7260, Prato, Maurizio ORCID: 0000-0002-8869-8612, Metin, Onder ORCID: 0000-0003-1622-4992 and Yilmazer, Acelya (2020). Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy. Small, 16 (10). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1613-6829

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Abstract

Thanks to its photocatalytic property, graphitic carbon nitride (g-C3N4) is a promising candidate in various applications including nanomedicine. However, studies focusing on the suitability of g-C3N4 for cancer therapy are very limited and possible underlying molecular mechanisms are unknown. Here, it is demonstrated that photoexcitation of g-C3N4 can be used effectively in photodynamic therapy, without using any other carrier or additional photosensitizer. Upon light exposure, g-C3N4 treatment kills cancer cells, without the need of any other nanosystem or chemotherapeutic drug. The material is efficiently taken up by tumor cells in vitro. The transcriptome and proteome of g-C3N4 and light treated cells show activation in pathways related to both oxidative stress, cell death, and apoptosis which strongly suggests that only when combined with light exposure, g-C3N4 is able to kill cancer cells. Systemic administration of the mesoporous form results in elimination from urinary bladder without any systemic toxicity. Administration of the material significantly decreases tumor volume when combined with local light treatment. This study paves the way for the future use of not only g-C3N4 but also other 2D nanomaterials in cancer therapy.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Taheri, HadisehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unal, Mehmet AltayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sevim, MelikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gurcan, CansuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekim, OkanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ceylan, AhmetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Syrgiannis, ZoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Christoforidis, Konstantinos C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosi, SusannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozgenc, OzgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez, Manuel JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turktas Erken, MineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soydal, CigdemUNSPECIFIEDorcid.org/0000-0002-6199-8551UNSPECIFIED
Eroglu, ZaferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bitirim, Ceylan VerdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cagin, UmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ari, FikretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozen, AsumanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kucuk, OzlemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delogu, Lucia GemmaUNSPECIFIEDorcid.org/0000-0002-2329-7260UNSPECIFIED
Prato, MaurizioUNSPECIFIEDorcid.org/0000-0002-8869-8612UNSPECIFIED
Metin, OnderUNSPECIFIEDorcid.org/0000-0003-1622-4992UNSPECIFIED
Yilmazer, AcelyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-348390
DOI: 10.1002/smll.201904619
Journal or Publication Title: Small
Volume: 16
Number: 10
Date: 2020
Publisher: WILEY-V C H VERLAG GMBH
Place of Publication: WEINHEIM
ISSN: 1613-6829
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUANTUM DOTS; GRAPHENE OXIDE; CELLULAR UPTAKE; NANOPARTICLES; PHOTOSENSITIZERS; DEGRADATION; GENERATION; NANOSHEETS; IMPACTMultiple languages
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed MatterMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34839

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