Universität zu Köln

Zlatopolskiy, Boris D., Endepols, Heike, Krasikova, Raisa N., Fedorova, Olga S., Ermert, Johannes ORCID: 0000-0002-2561-7766 and Neumaier, Bernd (2020). C-11- and F-18-labelled tryptophans as PET-tracers for imaging of altered tryptophan metabolism in age-associated disorders. Russ. Chem. Rev., 89 (9). S. 879 - 897. BRISTOL: TURPION LTD. ISSN 1468-4837

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Abstract

The ageing of the world's population is the result of increased life expectancy observed in almost all countries throughout the world. Consequently, a rising tide of ageing-associated disorders, like cancer and neurodegenerative diseases, represents one of the main global challenges of the 21st century. The ability of mankind to overcome these challenges is directly dependent on the capability to develop novel methods for therapy and diagnosis of age-associated diseases. One hallmark of age-related pathologies is an altered tryptophan metabolism. Numerous pathological processes including neurodegenerative and neurological diseases like epilepsy, Parkinson's and Alzheimer's diseases, cancer and diabetes exhibit marked changes in tryptophan metabolism. Visualization of key processes of tryptophan metabolic pathways, especially using positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI, can be exploited to early detect the aforementioned disorders with considerable accuracy, allowing appropriate and timely treatment of patients. Here we review the published C-11- and F-18-labelled tryptophans with respect to the production and also preclinical and clinical evaluation as PET-tracers for visualization of different branches of tryptophan metabolism.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zlatopolskiy, Boris D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Endepols, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Krasikova, Raisa N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorova, Olga S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ermert, Johannes UNSPECIFIED orcid.org/0000-0002-2561-7766 UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350387
DOI:	10.1070/RCR4954
Journal or Publication Title:	Russ. Chem. Rev.
Volume:	89
Number:	9
Page Range:	S. 879 - 897
Date:	2020
Publisher:	TURPION LTD
Place of Publication:	BRISTOL
ISSN:	1468-4837
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; METHYL-L-TRYPTOPHAN; BRAIN-SEROTONIN SYNTHESIS; AMINO-ACID TRANSPORTER; INDOLEAMINE 2,3-DIOXYGENASE; KYNURENINE PATHWAY; BIOLOGICAL EVALUATION; AUTOMATED SYNTHESIS; POTENTIAL AGENT; RHESUS-MONKEY Multiple languages Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35038