Universität zu Köln

Mulej Bratec, Satja ORCID: 0000-0003-2810-2095, Xie, Xiyao, Schmid, Gabriele, Doll, Anselm, Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Zimmer, Claus, Wohlschlaeger, Afra, Riedl, Valentin ORCID: 0000-0002-2861-8449 and Sorg, Christian (2015). Cognitive emotion regulation enhances aversive prediction error activity while reducing emotional responses. Neuroimage, 123. S. 138 - 149. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Cognitive emotion regulation is a powerful way of modulating emotional responses. However, despite the vital role of emotions in learning, it is unknown whether the effect of cognitive emotion regulation also extends to the modulation of learning. Computational models indicate prediction error activity, typically observed in the striatum and ventral tegmental area, as a critical neural mechanism involved in associative learning. We used model-based fMRI during aversive conditioning with and without cognitive emotion regulation to test the hypothesis that emotion regulation would affect prediction error-related neural activity in the striatum and ventral tegmental area, reflecting an emotion regulation-related modulation of learning. Our results show that cognitive emotion regulation reduced emotion-related brain activity, but increased prediction error-related activity in a network involving ventral tegmental area, hippocampus, insula and ventral striatum. While the reduction of response activity was related to behavioral measures of emotion regulation success, the enhancement of prediction error-related neural activity was related to learning performance. Furthermore, functional connectivity between the ventral tegmental area and ventrolateral prefrontal cortex, an area involved in regulation, was specifically increased during emotion regulation and likewise related to learning performance. Our data, therefore, provide first-time evidence that beyond reducing emotional responses, cognitive emotion regulation affects learning by enhancing prediction error-related activity, potentially via tegmental dopaminergic pathways. (C) 2015 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mulej Bratec, Satja UNSPECIFIED orcid.org/0000-0003-2810-2095 UNSPECIFIED Xie, Xiyao UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Doll, Anselm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Zimmer, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlschlaeger, Afra UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Valentin UNSPECIFIED orcid.org/0000-0002-2861-8449 UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386292
DOI:	10.1016/j.neuroimage.2015.08.038
Journal or Publication Title:	Neuroimage
Volume:	123
Page Range:	S. 138 - 149
Date:	2015
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOPAMINE NEURONS; PREFRONTAL CORTEX; NEURAL MECHANISMS; MODEL; FEAR; BRAIN; METAANALYSIS; UNCERTAINTY; VOLUNTARY; EVOLUTION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38629