Heindl, L. M., Koch, K. R., Schlaak, M., Mauch, C. and Cursiefen, C. (2015). Adjuvant therapy and interdisciplinary follow-up care of conjunctival melanoma. Ophthalmologe, 112 (11). S. 907 - 912. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423

Full text not available from this repository.

Abstract

Despite microscopically controlled tumor excision, malignant melanomas of the conjunctiva have a propensity for local recurrence, lymphatic spread and distant metastases. This review outlines the options of adjuvant therapy as well as the structure of interdisciplinary follow-up care for patients with conjunctival melanoma. The study provides a PubMed literature review and own clinical results. In conjunctival melanoma complete tumor excision using a minimal touch technique should always be combined with adjuvant therapy, such as cryotherapy, radiotherapy, topical chemotherapy and/or immunotherapy. For locally circumscribed lesions of the bulbar conjunctiva adjuvant brachytherapy can be supplemented and for non-bulbar, extensive, diffuse or multilocular tumor growth, complementary adjuvant topical mitomycin C therapy or proton radiotherapy can be used. Novel adjuvant approaches include topical interferon alpha-2b immunotherapy, topical vascular endothelial growth factor (VEGF) inhibitors or in cases of BRAF mutations personalized therapy using selective BRAF inhibitors or in combination with mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK), MAPK/ERK (MEK) inhibitors. All patients should be integrated into an interdisciplinary follow-up care program including quarter yearly checkups in the first 5 years and psycho-oncological healthcare. Following microscopically controlled tumor excision, adjuvant treatment using cryotherapy, radiotherapy, topical chemotherapy and/or immunotherapy as well as interdisciplinary follow-up care are mandatory for the modern management of patients with conjunctival melanoma.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heindl, L. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mauch, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-387950
DOI: 10.1007/s00347-015-0141-4
Journal or Publication Title: Ophthalmologe
Volume: 112
Number: 11
Page Range: S. 907 - 912
Date: 2015
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1433-0423
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PRIMARY ACQUIRED MELANOSIS; TUMOR-ASSOCIATED LYMPHANGIOGENESIS; AMERICAN JOINT COMMITTEE; TOPICAL MITOMYCIN-C; MALIGNANT-MELANOMA; IMPROVED SURVIVAL; MANAGEMENT; CRYOTHERAPY; BRAF; RECOMMENDATIONSMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38795

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item