Universität zu Köln

Tzschoppe, Anja, Riedel, Christina, von Kries, Ruediger, Struwe, Ellen, Rascher, Wolfgang, Doerr, Helmuth G., Beckmann, Matthias W., Schild, Ralf L., Goecke, Tamme W., Flyvbjerg, Allan, Frystyk, Jan and Doetsch, Joerg (2015). Differential effects of low birthweight and intrauterine growth restriction on umbilical cord blood insulin-like growth factor concentrations. Clin. Endocrinol., 83 (5). S. 739 - 746. HOBOKEN: WILEY. ISSN 1365-2265

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Abstract

ObjectiveAlterations in the growth hormone-insulin-like growth factor (IGF) axis have been considered as a causal factor for intrauterine growth restriction (IUGR) and for the increased risk of metabolic disease in later life. We compared members of the IGF axis in umbilical cord blood between IUGR neonates, small for gestational age without foetal restriction (SGA) and appropriate for gestational age (AGA) neonates. DesignProspective controlled multicenter study. PatientsSixteen ultrasound-proven IUGR, 8 SGA and 40 AGA neonates. MeasurementsConcentrations of total IGF-I and total IGF-II by immunoassays, bioactive IGF by cell-based bioassay and IGFBP-I in mixed venous and arterial umbilical cord blood samples at birth. Auxological parameters at birth. ResultsIGF-I concentrations in IUGR [177g/l (CI 138;216)] were clearly below those in AGA [483g/l (CI 437;529)] and SGA neonates [360g/l (CI 266;454)]. IGF-II levels were significantly reduced in IUGR [2014g/l (CI 1902;2126)] compared to AGA neonates [2312g/l (CI 2206;2419)]. A trend for lower IGF-II concentrations was observed in IUGR when compared to SGA neonates [2320g/l (CI 2072;2568)]. These differences could not be explained by confounding. For IGFBP-1, a trend towards higher values in IUGR was observed. ConclusionsLow IGF-I cord blood concentrations in hypotrophic neonates after IUGR might not only result from low birthweight per se, but also reflect prenatal placental environment. Alterations of the IGF axis could be in the causal pathway of IUGR and thus constitute a potential surrogate marker for IUGR in the assessment of foetal programming.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tzschoppe, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED von Kries, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Struwe, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rascher, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerr, Helmuth G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beckmann, Matthias W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Ralf L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goecke, Tamme W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Flyvbjerg, Allan UNSPECIFIED UNSPECIFIED UNSPECIFIED Frystyk, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388394
DOI:	10.1111/cen.12844
Journal or Publication Title:	Clin. Endocrinol.
Volume:	83
Number:	5
Page Range:	S. 739 - 746
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2265
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOR-GESTATIONAL-AGE; FETAL-GROWTH; FACTOR-I; DEVELOPMENTAL ORIGINS; BINDING-PROTEINS; SHORT CHILDREN; FACTOR SYSTEM; HORMONE; RETARDATION; GHRELIN Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38839