Universität zu Köln

Markser, A., Maier, Franziska, Lewis, C. J., Dembek, T. A., Pedrosa, D., Eggers, C., Timmermann, L., Kalbe, E., Fink, G. R. and Burghaus, Lothar (2015). Deep brain stimulation and cognitive decline in Parkinson's disease: The predictive value of electroencephalography. J. Neurol., 262 (10). S. 2275 - 2285. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

Some Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) develop new-onset cognitive decline. We examined whether clinical EEG recordings can be used to predict cognitive deterioration in PD patients undergoing STN-DBS. In this retrospective study, we used the Grand Total EEG (GTE)-score (short and total) to evaluate pre- and postoperative EEGs. In PD patients undergoing STN-DBS (N = 30), cognitive functioning was measured using Mini-Mental State Test and DemTect before and after surgery. Severity of motor impairment was assessed using the Unified Parkinson's Disease Rating Scale-III. Patients were classified into patients with or without cognitive decline after STN-DBS surgery. Epidemiological data, pre- and postoperative EEG recordings as well as neuropsychological and neurological data, electrode positions and the third ventricle width were compared. A logistic regression model was used to identify predictors of cognitive decline. Motor deficits significantly improved from pre- to post-surgery, while the mean GTE-scores increased significantly. Six patients developed cognitive deterioration 4-12 months postoperatively. These patients had significantly higher preoperative GTE-scores than patients without cognitive deterioration, although preoperative cognitive functioning was comparable. Electrode positions, brain atrophy and neurological data did not differ between groups. Logistic regression analysis identified the GTE-score as a significant predictor of postoperative cognitive deterioration. Data suggest that the preoperative GTE-score can be used to identify PD patients that are at high risk for developing cognitive deterioration after STN-DBS surgery even though their preoperative cognitive state was normal.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Markser, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, C. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, T. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedrosa, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burghaus, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-392124
DOI:	10.1007/s00415-015-7839-8
Journal or Publication Title:	J. Neurol.
Volume:	262
Number:	10
Page Range:	S. 2275 - 2285
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BILATERAL SUBTHALAMIC STIMULATION; MINI-MENTAL-STATE; NUCLEUS STIMULATION; EARLY DEMENTIA; EEG; IMPACT; IMPAIRMENT; DIAGNOSIS; DEMTECT Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39212