Universität zu Köln

Abbas, M., Daemmrich, M. E., Braubach, P., Kramer, M. W., Gruenwald, V., Merseburger, A. S., Herrmann, T. R. W., Becker, J. U. and Kreipe, H. H. (2015). Role of immunohistochemistry and fluorescence in-situ hybridization (FISH) in the diagnosis of spindle and round cell tumors of the kidney. J. Egypt. Natl. Cancer Inst., 27 (3). S. 173 - 179. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1687-9996

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Abstract

Spindle cell/mesenchymal tumors of the kidney are rare. The diagnosis is supported mainly by the application of ancillary techniques such as immunohistochemistry (IH) and in-situ hybridization (FISH). An accurate diagnosis is essential because early management by complete resection and adjuvant chemotherapy improves the prognosis dramatically. Synovial sarcoma and primitive neuroectodermal tumor/Ewing sarcoma are infrequent malignancies which usually present in soft tissues but rarely in the kidney. The challenge for the pathologists is to histologically differentiate between different types of sarcomas such as PNET/Ewing's sarcoma, sarcomatous dedifferentiated renal cell carcinoma, metastasis, non-Hodgkin's lymphoma, nephroblastoma and angiomyolipoma. Methods: We report from our experience six exemplary rare cases that presented in the kidney as spindle/round cell tumors. Results: We have arrived at the accurate diagnosis after performing a large panel of IH and FISH. Conclusion: In summary we advise an immunohistochemical panel for round/spindle cell tumors of the kidney and for unclear cases we advise to add (FISH) to get the correct diagnosis, as they are completely different regarding surgical approach and post-operative adjuvant therapy. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of National Cancer Institute, Cairo University.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Abbas, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Daemmrich, M. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Braubach, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramer, M. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenwald, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merseburger, A. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrmann, T. R. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, J. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreipe, H. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395661
DOI:	10.1016/j.jnci.2015.04.005
Journal or Publication Title:	J. Egypt. Natl. Cancer Inst.
Volume:	27
Number:	3
Page Range:	S. 173 - 179
Date:	2015
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1687-9996
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39566