Universität zu Köln

Clemen, Christoph S., Marko, Marija, Strucksberg, Karl-Heinz, Behrens, Juliane, Wittig, Ilka, Gaertner, Linda, Winter, Lilli ORCID: 0000-0002-6368-1160, Chevessier, Frederic, Matthias, Jan, Tuerk, Matthias, Tangavelou, Karthikeyan, Schuetz, Johanna, Arhzaouy, Khalid, Klopffleisch, Karsten, Hanisch, Franz-Georg, Rottbauer, Wolfgang, Bluemcke, Ingmar, Just, Steffen, Eichinger, Ludwig ORCID: 0000-0003-1594-6117, Hofmann, Andreas ORCID: 0000-0003-4408-5467 and Schroeder, Rolf (2015). VCP and PSMF1: Antagonistic regulators of proteasome activity. Biochem. Biophys. Res. Commun., 463 (4). S. 1210 - 1218. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2104

Full text not available from this repository.

Abstract

Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/hy-nc-nd/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Clemen, Christoph S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marko, Marija UNSPECIFIED UNSPECIFIED UNSPECIFIED Strucksberg, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrens, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittig, Ilka UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaertner, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Winter, Lilli UNSPECIFIED orcid.org/0000-0002-6368-1160 UNSPECIFIED Chevessier, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthias, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Tuerk, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Tangavelou, Karthikeyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuetz, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Arhzaouy, Khalid UNSPECIFIED UNSPECIFIED UNSPECIFIED Klopffleisch, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanisch, Franz-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottbauer, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Bluemcke, Ingmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Just, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichinger, Ludwig UNSPECIFIED orcid.org/0000-0003-1594-6117 UNSPECIFIED Hofmann, Andreas UNSPECIFIED orcid.org/0000-0003-4408-5467 UNSPECIFIED Schroeder, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-396573
DOI:	10.1016/j.bbrc.2015.06.086
Journal or Publication Title:	Biochem. Biophys. Res. Commun.
Volume:	463
Number:	4
Page Range:	S. 1210 - 1218
Date:	2015
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2104
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VALOSIN-CONTAINING PROTEIN; CELLULAR ROLES; REVEALS; NETWORK; PI31; DEGRADATION; INHIBITOR; BINDING; PA28; ERAD Multiple languages Biochemistry & Molecular Biology; Biophysics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39657