Koch, Manja ORCID: 0000-0002-4794-4821, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Schlesinger, Sabrina ORCID: 0000-0003-4244-0832, Barbaresko, Janett ORCID: 0000-0003-0855-2769, Groth, Godo, Jacobs, Gunnar, Lieb, Wolfgang, Laudes, Matthias, Mueller, Manfred J., Bosy-Westphal, Anja, Heller, Martin and Noethlings, Ute (2015). Association of a lifestyle index with MRI-determined liver fat content in a general population study. J. Epidemiol. Community Health, 69 (8). S. 732 - 738. LONDON: BMJ PUBLISHING GROUP. ISSN 1470-2738
Full text not available from this repository.Abstract
Background In prior studies, lifestyle indices were associated with numerous disease end points, but the association with fatty liver disease (FLD), a key correlate of cardiometabolic risk, is unknown. The aim was to investigate associations between a lifestyle index with liver fat content. Methods Liver fat was quantified by MRI as liver signal intensity (LSI) in 354 individuals selected from a population-based cohort from Germany. Exposure to favourable lifestyle factors was quantified using an additive score with each factor modelled as a dichotomous trait. Favourable lifestyle factors were defined as waist circumference below 102 (men) or 88 cm (women), physical activity >= 3.5 h/week, never-smoking and a favourable dietary pattern, which was derived to explain liver fat variation. In a cross-sectional study, multivariable adjusted linear and logistic regression was applied to investigate the association between the lifestyle index (range 0-4, exposure) and LSI (modelled as a continuous trait or dichotomised as a FLD indicator variable, respectively). Results Individuals with four favourable lifestyle factors (n=9%) had lower LSI values (beta -0.40; 95% CI -0.61 to -0.19) and a lower OR (0.09; 95% CI 0.03 to 0.30) for FLD compared with individuals with zero favourable lifestyle factors (n=10%). Conclusions A healthy lifestyle pattern was associated with less liver fat. Prospective studies are warranted.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-398361 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1136/jech-2014-204989 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | J. Epidemiol. Community Health | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 69 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | S. 732 - 738 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Date: | 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | BMJ PUBLISHING GROUP | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1470-2738 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/39836 |
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