Kohler, Maxie, Schaenzer, Wilhelm and Thevis, Mario (2015). Effects of Exercise on the Urinary Proteome. In: Advances in Experimental Medicine and Biology, S. 121 - 132. BERLIN: SPRINGER-VERLAG BERLIN. ISBN 978-94-017-9523-4; 978-94-017-9522-7

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Abstract

Exercise-induced proteinuria has been observed and studied for more than a century. It was found that different sport disciplines alter the urinary proteome in different ways. Moderate-intensity exercise results in increased glomerular filtration, meaning that medium-sized proteins are excreted in higher amounts, while high-intensity exercise of short duration also increases the excretion of low molecular weight proteins as a result of tubular dysfunction. Exhaustive exercise may lead to the excretion of hemoglobin or myoglobin, which changes the urinary proteome considerably. Studies comparing protein maps of different sport types compared to a control group showed that quality and quantity of urinary proteins are interindividually different. In addition, urine samples collected before and after exercise exhibit substantially different protein patterns even from the same person. Therefore, further studies investigating the urinary proteome are desirable. As the variation of protein content and composition in urine are generally much higher than in other matrices, respective studies need to be well controlled and homogenous groups of volunteers should be chosen. In addition to the sport-related physiological and biochemical interest, exercise-induced protein changes also need to be considered for biomarker measurements from urine samples for kidney or other diseases.

Item Type: Book Section, Proceedings Item or annotation in a legal commentary
Creators:
CreatorsEmailORCIDORCID Put Code
Kohler, MaxieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaenzer, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thevis, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-417144
DOI: 10.1007/978-94-017-9523-4_12
Title of Book: Advances in Experimental Medicine and Biology
Series Name: Adv.Exp.Med.Biol.
Volume: 845
Page Range: S. 121 - 132
Date: 2015
Publisher: SPRINGER-VERLAG BERLIN
Place of Publication: BERLIN
ISSN: 0065-2598
ISBN: 978-94-017-9523-4; 978-94-017-9522-7
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACUTE KIDNEY INJURY; POSTEXERCISE PROTEINURIA; ELECTROPHORESIS; BIOMARKERS; INTENSITY; HEMATURIA; EXCRETION; DURATION; HEALTHY; ALBUMINMultiple languages
Biology; Medicine, Research & Experimental; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41714

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