Schneider, T., Dibue-Adjei, M., Neumaier, F., Akhtar, I., Hescheler, J., Kamp, M. A. and Tevoufouet, E. E. (2015). R-Type Voltage-Gated Ca2+ Channels in Cardiac and Neuronal Rhythmogenesis. Curr. Molec. Pharmacol., 8 (1). S. 102 - 109. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1874-4702

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Abstract

During the past decades, an increasing number of ion channel and transporter types have been identified acting together to produce cardiac and neuronal pacemaker action potentials. The basis of pacemaker activity was understood in more detail by using single-microelectrode recordings on cells isolated from pacemaker regions. Meanwhile, this powerful technique was complemented by computer modeling and recombinant technologies, including gene inactivation of ion channels and transporters, which may be involved in the generation of the electrical activity of pacemaker cells. Several genes of the voltage-gated Ca2+ channel (VGCC) family have been ablated, and their role in cardiac and neuronal pacemaking is compared in the present summary, focusing on the role of murine R-type voltage-gated Ca2+ channels encoded by cacna1e and expressing the ion conducting subunit Ca(v)2.3.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schneider, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dibue-Adjei, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akhtar, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hescheler, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamp, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tevoufouet, E. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-418680
DOI: 10.2174/1874467208666150507093845
Journal or Publication Title: Curr. Molec. Pharmacol.
Volume: 8
Number: 1
Page Range: S. 102 - 109
Date: 2015
Publisher: BENTHAM SCIENCE PUBL LTD
Place of Publication: SHARJAH
ISSN: 1874-4702
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Biochemistry & Molecular Biology; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41868

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