Universität zu Köln

Dunkl, Veronika, Cleff, Corvin, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Judov, Natalie ORCID: 0000-0002-3909-9306, Sarikaya-Seiwert, Sevgi, Law, Ian ORCID: 0000-0001-9644-7496, Bogeskov, Lars, Nysom, Karsten, Andersen, Sofie B., Steiger, Hans-Jakob, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Reifenberger, Guido, Shah, Nadim J., Coenen, Heinz H., Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2015). The Usefulness of Dynamic O-(2-F-18-Fluoroethyl)-L-Tyrosine PET in the Clinical Evaluation of Brain Tumors in Children and Adolescents. J. Nucl. Med., 56 (1). S. 88 - 93. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Experience regarding O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) PET in children and adolescents with brain tumors is limited. Methods: Sixty-nine F-18-FET PET scans of 48 children and adolescents (median age, 13 y; range, 1-18 y) were analyzed retrospectively. Twenty-six scans to assess newly diagnosed cerebral lesions, 24 scans for diagnosing tumor progression or recurrence, 8 scans for monitoring of chemotherapy effects, and 11 scans for the detection of residual tumor after resection were obtained. Maximum and mean tumor-tobrain ratios (TBRs) were determined at 20-40 min after injection, and time-activity curves of F-18-FET uptake were assigned to 3 different patterns: constant increase; peak at greater than 20-40 min after injection, followed by a plateau; and early peak (<= 20 min), followed by a constant descent. The diagnostic accuracy of F-18-FET PET was assessed by receiver-operating-characteristic curve analyses using histology or clinical course as a reference. Results: In patients with newly diagnosed cerebral lesions, the highest accuracy (77%) to detect neoplastic tissue (19/26 patients) was obtained when the maximum TBR was 1.7 or greater (area under the curve, 0.80 +/- 0.09; sensitivity, 79%; specificity, 71%; positive predictive value, 88%; P = 0.02). For diagnosing tumor progression or recurrence, the highest accuracy (82%) was obtained when curve patterns 2 or 3 were present (area under the curve, 0.80 +/- 0.11; sensitivity, 75%; specificity, 90%; positive predictive value, 90%; P = 0.02). During chemotherapy, a decrease of TBRs was associated with a stable clinical course, and in 2 patients PET detected residual tumor after presumably complete tumor resection. Conclusion: Our findings suggest that F-18-FET PET can add valuable information for clinical decision making in pediatric brain tumor patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dunkl, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Cleff, Corvin UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Judov, Natalie UNSPECIFIED orcid.org/0000-0002-3909-9306 UNSPECIFIED Sarikaya-Seiwert, Sevgi UNSPECIFIED UNSPECIFIED UNSPECIFIED Law, Ian UNSPECIFIED orcid.org/0000-0001-9644-7496 UNSPECIFIED Bogeskov, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Nysom, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Andersen, Sofie B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiger, Hans-Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Reifenberger, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-419209
DOI:	10.2967/jnumed.114.148734
Journal or Publication Title:	J. Nucl. Med.
Volume:	56
Number:	1
Page Range:	S. 88 - 93
Date:	2015
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; LOW-GRADE GLIOMA; F-18-FET PET; FET PET; DIFFERENTIAL UPTAKE; MALIGNANT GLIOMA; CEREBRAL GLIOMAS; DIAGNOSTIC-TOOL; UPTAKE KINETICS; AMINO-ACID Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41920