Malhotra, Rakesh, Marcelli, Daniele ORCID: 0000-0002-7650-8578, von Gersdorff, Gero, Grassmann, Aileen, Schaller, Mathias, Bayh, Inga, Scatizzi, Laura, Etter, Michael, Guinsburg, Adrian ORCID: 0000-0001-8770-1894, Barth, Claudia, Marelli, Cristina, Carioni, Paola, van der Sande, Frank, Kooman, Jeroen P., Liu, Eric, Toffelmire, Ted, Wang, Yuedong, Thijssen, Stephan, Usvyat, Len A. and Kotanko, Peter ORCID: 0000-0003-4373-412X (2015). Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive Protein in Hemodialysis Patients: Results from 2 International Cohort Studies. Nephron, 130 (4). S. 263 - 271. BASEL: KARGER. ISSN 2235-3186

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Abstract

Background/Aim: The neutrophil-to-lymphocyte ratio (NLR), defined as the neutrophil count divided by lymphocyte count, is an inexpensive and readily available parameter, which may serve as a surrogate for inflammation markers, such as C-reactive protein (CRP). The aim of this study was to determine the utility of NLR in the prediction of elevated CRP levels in hemodialysis (HD) patients. Methods: We analyzed 43,272 HD patients from 2 distinct cohorts within the Monitoring Dialysis Outcomes research collaboration in whom contemporaneous measurements of neutrophil and lymphocyte counts, serum albumin and CRP levels were available. Logistic regression was used to determine the relationship of trichotomized NLR (<2.5, 2.5-5 and >5.0) and albumin levels (<3.1, 3.1-4.0 and >4.0 g/dl) with elevated CRP levels (>10.0, >20.0 and >30.0 mg/l). Congruence of the prediction models was examined by comparing the regression parameters and by cross-validating each regression equation within the other cohort. Results: We found that NLR >5.0 vs. <2.5 (cohort 1: OR 2.3; p < 0.0001 and cohort 2: OR 2.0; p < 0.0001) was associated with CRP levels >10.0 mg/l. Stepwise increase in odds ratio for CRP >10.0 mg/l was observed with the combination of high NLR and low albumin levels (NLR >5.0 and albumin <3.1) (cohort 1: OR 7.6; p < 0.0001 and cohort 2: OR 11.9; p < 0.0001). Cross-validation of the 2 regression models revealed a predictive accuracy of 0.68 and 0.69 in the respective cohorts. Conclusion: This study suggests that NLR could serve as a potential surrogate marker for CRP. Our results may add to diagnostic abilities in settings where CRP is not measured routinely in HD patients. NLR is easy to integrate into daily practice and may be used as a marker of systemic inflammation. (C) 2015 S. Karger AG, Basel

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Malhotra, RakeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marcelli, DanieleUNSPECIFIEDorcid.org/0000-0002-7650-8578UNSPECIFIED
von Gersdorff, GeroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grassmann, AileenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaller, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayh, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scatizzi, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Etter, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guinsburg, AdrianUNSPECIFIEDorcid.org/0000-0001-8770-1894UNSPECIFIED
Barth, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marelli, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carioni, PaolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Sande, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kooman, Jeroen P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toffelmire, TedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, YuedongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thijssen, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Usvyat, Len A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kotanko, PeterUNSPECIFIEDorcid.org/0000-0003-4373-412XUNSPECIFIED
URN: urn:nbn:de:hbz:38-419518
DOI: 10.1159/000437005
Journal or Publication Title: Nephron
Volume: 130
Number: 4
Page Range: S. 263 - 271
Date: 2015
Publisher: KARGER
Place of Publication: BASEL
ISSN: 2235-3186
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CORONARY-HEART-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; DIALYSIS PATIENTS; INFLAMMATION; MORTALITY; ASSOCIATION; BIOMARKERS; HOSPITALIZATION; INTERLEUKIN-6Multiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41951

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