Neogi, Ujjwal ORCID: 0000-0002-0844-3338, Rao, Shwetha D., Bontell, Irene, Verheyen, Jens, Rao, Vasudev R., Gore, Sagar C., Soni, Neelesh ORCID: 0000-0002-9333-7491, Shet, Anita ORCID: 0000-0002-7204-8164, Schuelter, Eugen, Ekstrand, Maria L., Wondwossen, Amogne, Kaiser, Rolf, Madhusudhan, Mallur S., Prasad, Vinayaka R. and Sonnerborg, Anders ORCID: 0000-0001-8928-3374 (2014). Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients. Aids, 28 (15). S. 2319 - 2323. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P<0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Neogi, UjjwalUNSPECIFIEDorcid.org/0000-0002-0844-3338UNSPECIFIED
Rao, Shwetha D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bontell, IreneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verheyen, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rao, Vasudev R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gore, Sagar C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soni, NeeleshUNSPECIFIEDorcid.org/0000-0002-9333-7491UNSPECIFIED
Shet, AnitaUNSPECIFIEDorcid.org/0000-0002-7204-8164UNSPECIFIED
Schuelter, EugenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekstrand, Maria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wondwossen, AmogneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Madhusudhan, Mallur S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, Vinayaka R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sonnerborg, AndersUNSPECIFIEDorcid.org/0000-0001-8928-3374UNSPECIFIED
URN: urn:nbn:de:hbz:38-429845
DOI: 10.1097/QAD.0000000000000419
Journal or Publication Title: Aids
Volume: 28
Number: 15
Page Range: S. 2319 - 2323
Date: 2014
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1473-5571
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACTIVE ANTIRETROVIRAL THERAPY; TRANSMITTED DRUG-RESISTANCE; NAIVE INDIVIDUALS; LATE DOMAINS; REGION; MUTATIONS; SELECTION; P6(GAG); GENEMultiple languages
Immunology; Infectious Diseases; VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42984

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