Universität zu Köln

Beuth, Josef, van Leendert, Rudolf, Pempelfort, Kirsten, Schneider, Berthold, Grund, Christina and Engelmann, Udo (2014). Complementary Medicine Down-regulates Side-effects of Hormone Therapy in Prostate Cancer Patients. In Vivo, 28 (5). S. 979 - 983. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7549

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Abstract

Aim: The present clinical investigation was performed to evaluate the benefits of complementary medicine in prostate cancer patients undergoing hormone therapy (HT). Patients and Methods: Patients (N=93) were treated according to international guidelines. All patients suffered from side-effects induced by the HT. To reduce the side-effects, the patients were complementarily treated with a combination of sodium selenite, proteolytic plant enzymes and Lens culinaris (Lc) lectin. On case report formulas (CRFs), self assessment of defined side-effects of HT (arthralgia, mucosal dryness, bone pain and hot flushes) were documented before (T-0) and on days 25 (T-1) and 50 (T-2) after complementary treatment. Validation was carriedout by scoring from 1 (no side-effects/optimal tolerability) to 6 (extreme side-effects/extremely bad tolerability), however, only patients suffering from severe side-effects (symptom scores >3) were enrolled in this investigation. Results: The severity of side-effects of HT was reduced by complementary treatment with sodium selenite, proteolytic plant enzymes and Lc-lectin. The mean scores of side-effects declined for arthralgia from 4.72 (T-0) to 3.66 (T-1) to 2.76 (T-2), for mucosal dryness from 4.45 (T-0) to 3.65 (T-1) to 2.90 (T-2), for bone pain from 4.74 (T-0) to 3.44 (T-1) to 2.82 (T-2), for hot flushes from 4.97 (T-0) to 3.70 (T-1) to 3.15 (T-2). The reduced severity of the side-effects was statistically significant (p<0.001) for T-1 and T-2, compared to T-0. Conclusion: This investigation demonstrates benefits of indication-based complementary treatment with the combination of sodium selenite, proteolytic plant enzymes and Lc-lectin in prostate cancer patients, e.g. reduction of side-effects of HT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Beuth, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED van Leendert, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Pempelfort, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Berthold UNSPECIFIED UNSPECIFIED UNSPECIFIED Grund, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelmann, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-430600
Journal or Publication Title:	In Vivo
Volume:	28
Number:	5
Page Range:	S. 979 - 983
Date:	2014
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7549
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43060