Salokangas, R. K. R., Heinimaa, M., From, T., Loyttyniemi, E., Ilonen, T., Luutonen, S., Hietala, J., Svirskis, T., von Reventlow, H. G., Juckel, G., Linszen, D., Dingemans, P., Birchwood, M., Patterson, P., Schultze-Lutter, F., Ruhrmann, S. and Klosterkoetter, J. (2014). Short-term functional outcome and premorbid adjustment in clinical high-risk patients. Results of the EPOS project. Eur. Psychiat., 29 (6). S. 371 - 381. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1778-3585

Full text not available from this repository.

Abstract

Purpose: In patients with schizophrenia, premorbid psychosocial adjustment is an important predictor of functional outcome. We studied functional outcome in young clinical high-risk (CHR) patients and how this was predicted by their childhood to adolescence premorbid adjustment. Methods: In all, 245 young help-seeking CHR patients were assessed with the Premorbid Adjustment Scale, the Structured Interview for Prodromal Syndromes (SIPS) and the Schizophrenia Proneness Instrument (SPI-A). The SIPS assesses positive, negative, disorganised, general symptoms, and the Global Assessment of Functioning (GAF), the SPI-A self-experienced basic symptoms; they were carried out at baseline, at 9-month and 18-month follow-up. Transitions to psychosis were identified. In the hierarchical linear model, associations between premorbid adjustment, background data, symptoms, transitions to psychosis and GAF scores were analysed. Results: During the 18-month follow-up, GAF scores improved significantly, and the proportion of patients with poor functioning decreased from 74% to 37%. Poor premorbid adjustment, single marital status, poor work status, and symptoms were associated with low baseline GAF scores. Low GAF scores were predicted by poor premorbid adjustment, negative, positive and basic symptoms, and poor baseline work status. The association between premorbid adjustment and follow-up GAF scores remained significant, even when baseline GAF and transition to psychosis were included in the model. Conclusion: A great majority of help-seeking CHR patients suffer from deficits in their functioning. In CHR patients, premorbid psychosocial adjustment, baseline positive, negative, basic symptoms and poor working/schooling situation predict poor short-term functional outcome. These aspects should be taken into account when acute intervention and long-term rehabilitation for improving outcome in CHR patients are carried out. (C) 2013 Elsevier Masson SAS. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Salokangas, R. K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinimaa, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
From, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loyttyniemi, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilonen, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luutonen, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hietala, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Svirskis, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Reventlow, H. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juckel, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linszen, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dingemans, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Birchwood, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patterson, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-432747
DOI: 10.1016/j.eurpsy.2013.10.003
Journal or Publication Title: Eur. Psychiat.
Volume: 29
Number: 6
Page Range: S. 371 - 381
Date: 2014
Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication: ISSY-LES-MOULINEAUX
ISSN: 1778-3585
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; 1ST EPISODE PSYCHOSIS; ULTRA-HIGH RISK; FOLLOW-UP; 1ST-EPISODE PSYCHOSIS; VOCATIONAL-REHABILITATION; GENDER-DIFFERENCES; NEGATIVE SYMPTOMS; YOUNG-ADULTSMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43274

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item